1365543-59-4

Upstream product

• 851008-48-5 1-(cyclopropylsulphanyl)-4-nitrobenzene 
• 354-38-1 2,2,2-trifluoroacetamide 
• 1849-36-1 para-nitrobenzenethiol 

Downstream Products

• 1365544-29-1 (2S,3S)-2,3-bis[(4-methylbenzoyl)oxy]butanedioic acid 1-(R)-(cyclopropylsulphonimidoyl)-4-nitrobenzene 
• 1365544-25-7 N-[(R)-cyclopropyl(4-nitrophenyl)oxido-lambda⁶-sulphanylidene]-2,2,2-trifluoroacetamide 
• 1365543-92-5 N-[(R)-(4-aminophenyl)(cyclopropyl)oxido-lambda⁶-sulphanylidene]-2,2,2-trifluoroacetamide 
• 1223498-69-8 (R)-S-cyclopropyl-S-(4-{[4-{[(1R, 2R)-2-hydroxy-1-methylpropyl]oxy}-5-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)sulphoximide 
• 1365543-64-1 N-[(4-{[4-{[(2R,3R)-3-(benzyloxy)butan-2-yl]oxy}-5-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)(cyclopropyl)oxido-lambda⁶-sulphanylidene]-2,2,2-trifluoroacetamide benzenesulphonic acid salt 

Relevant academic research and scientific papers

A practical approach to N-(trifluoroacetyl)sulfilimines

A new, simple method for the synthesis of N-(trifluoroacetyl)-protected sulfilimines from sulfides by a transition-metal-free, one-pot protocol is presented. The salient features of this process include the use of low-cost 1,3-dibromo-5,5-dimethylhydantoin, mild reaction conditions, and a broad substrate scope. The safety and robustness of the method has also been demonstrated by operations on a kilogram scale. In addition, a chiral resolution of a corresponding sulfoximine was achieved on a large scale. Georg Thieme Verlag Stuttgart. New York.

PROCESS FOR PREPARING PAN-CDK INHIBITORS OF THE FORMULA (I), AND INTERMEDIATES IN THE PREPARATION

The invention relates to a novel process for the preparation of pan-CDK inhibitors of the formula (I), and intermediates of the preparation.