1365549-52-5

Basic information

• Product Name: C₃₅H₃₈O₆
• CAS NO: 1365549-52-5
• Molecular Weight: 554.683
• Mol File: 1365549-52-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₃₅H₃₈O₆(CAS DataBase Reference)
• NIST Chemistry Reference: C₃₅H₃₈O₆(1365549-52-5)
• EPA Substance Registry System: C₃₅H₃₈O₆(1365549-52-5)

Safety Data

• Hazardous Substances Data: 1365549-52-5(Hazardous Substances Data)

Upstream product

• 65-85-0 benzoic acid 
• 82684-06-8 methyl (4aR,10aS)-5,6-dihydroxy-7-isopropyl-1,1-dimethyl-1,3,4,9,10,10a-hexahydrophenanthrene-4a(2H)-carboxylate 
• 3650-09-7 carnosic acid 

Relevant articles and documents

Gastroprotective effect and cytotoxicity of carnosic acid derivatives

Carnosic acid (CA) is the main phenolic diterpene of rosemary (Rosmarinus officinalis L., Lamiaceae) and presents gastroprotective effect in vitro and in vivo. To determine structure-activity relationships, seventeen esters and ethers of CA were prepared, comprising aliphatic, aromatic, and heterocyclic compounds. The naturally occurring 12-O-methylcarnosic acid (14) was also included in the study. The compounds were evaluated for their gastroprotective activity in the HCl/EtOH-induced gastric lesions model in mice, and for cytotoxicity in human adenocarcinoma AGS cells, Hep G2 hepatocellular carcinoma cells, and human lung fibroblasts. At 10 mg/kg, some of the CA derivatives (5, 8, 9, 12, 14, and 18) were more effective preventing gastric lesions than the reference compound lansoprazole at the same dose. The dibenzoate 9, diindoleacetate 12, and the derivative 18 showed the best gastroprotective effect combined with the lowest cytotoxicity. Georg Thieme Verlag KG Stuttgart.