136564-72-2Relevant academic research and scientific papers
Carbamoyl derivatives
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, (2008/06/13)
The present invention concerns novel carbamoyl derivatives of formula I, set out herein, which antagonize the pharmacological actions of one or more of the arachidonic acid metabolites known as leukotrienes, making them useful whenever such antagonism is desired, such as in the treatment of those diseases in which leukotrienes are implicated, for example, in the treatment of allergic or inflammatory diseases, or of endotoxic or traumatic shock conditions. The invention also provides pharmaceutical compositions containing the novel derivatives for use in such treatments, methods for their use and processes and intermediates for the manufacture of the novel derivatives.
Substituted 3-(Phenylmethyl)-1H-indole-5-carboxamides and 1-(Phenylmethyl)indole-6-carboxamides as Potent, Selective, Orally Active Antagonists of the Peptidoleukotrienes
Jacobs, Robert T.,Brown, Frederick J.,Cronk, Laura A.,Aharony, David,Buckner, Carl K.,et al.
, p. 394 - 409 (2007/10/02)
Substituted indole-5-caboxamides and indole-6-carboxamides have been found to be potent and selective antagonists of the peptidoleukotrienes.Initial derivatives of these series (4--1-methylindol-3-yl>methyl>-3-methoxy-N-
