1365769-28-3

Upstream product

• 1365769-39-6 (2R,3S,4S,5R,6S)-2-(acetoxymethyl)-6-(4-((2-formyl-5-(prop-2-yn-1-yloxy)phenoxy)methyl)phenoxy)tetrahydro-2H-pyran-3,4,5-triyl triacetate 
• 105-53-3 diethyl malonate 
• 106-44-5 p-cresol 
• 74808-10-9 O-(2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl)trichloroacetimidate 
• 3520-64-7 p-methylphenyl 2,3,4,6-tetra-O-acetyl-1-thio-β-D-galactopyranoside 

Downstream Products

• 1365769-47-6 dimethyl 2-(4-(prop-2-yn-1-yloxy)-2-((4-(((2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)benzyl)oxy)benzylidene)malonate 

Relevant academic research and scientific papers

Multiplex detection of enzymatic activity with responsive lanthanide-based luminescent probes

Multiplex analyte detection in complex dynamic systems is desirable for the investigation of cellular communication networks as well as in medical diagnostics. A family of lanthanide-based responsive luminescent probes for multiplex detection is reported. The high modularity of the probe design enabled the rapid assembly of both green and red emitters for a large variety of analytes by the simple exchange of the lanthanide or an analyte-cleavable caging group, respectively. The real-time three-color detection of up to three analytes was demonstrated, thus setting the stage for the non-invasive investigation of interconnected biological processes. © 2015 Wiley-VCH Verlag GmbH & Co. KGaA , Weinheim.

Luminescent lanthanide complexes with analyte-triggered antenna formation

A new strategy for accessing analyte-responsive luminescent probes is presented. The lanthanide luminescence of Eu and Tb centers is switched on by the analyte-triggered formation of a sensitizing antenna from a nonsensitizing caged precursor. As the cage can be freely varied, an array of probes for different analytes (Pd0/2+, H2O2, F -, β-galactosidase) can be created from the same core structure. The probe design affords nanomolar to micromolar detection limits, provides the capability to detect two analytes in parallel, and can be utilized to monitor enzymatic activity in live cells.