13658-68-9Relevant academic research and scientific papers
Self-assembly of a new 3D platelike ternary-oxo-cluster: An efficient catalyst for the synthesis of pyrazoles
Yang, Guoping,Liu, Yufeng,Lin, Xiaoling,Ming, Bangming,Li, Ke,Hu, Changwen
, p. 354 - 357 (2022)
A new metal-oxo-clusters-based inorganic framework [NaCo2Mo2O7(OH)3]n (NaCoMo), named as 3D platelike ternary-oxo-cluster, has been hydrothermally synthesized and characterized by single-crystal X-ray
2D network structure of zinc(II) complex: A new easily accessible and efficient catalyst for the synthesis of pyrazoles
Cao, Gang-Ming,Zeng, Guo-Dong,Li, Ke,Liu, Yu-Feng,Lin, Xiao-Ling,Yang, Guo-Ping
, (2021/07/16)
A Zn(II) coordination polymer {[Zn3(paz)(btc)2(H2O)8]·4H2O}n (noted as ZnPB), where paz = pyrazine, H3btc = trimesic acid, was synthesized and characterized by single-crystal X-r
Direct N-heterocyclization of hydrazines to access styrylated pyrazoles: synthesis of 1,3,5-trisubstituted pyrazoles and dihydropyrazoles
Venkateswarlu, Vunnam,Kour, Jaspreet,Kumar, K. A. Aravinda,Verma, Praveen Kumar,Reddy, G. Lakshma,Hussain, Yaseen,Tabassum, Aliya,Balgotra, Shilpi,Gupta, Sorav,Hudwekar, Abhinandan D.,Vishwakarma, Ram A.,Sawant, Sanghapal D.
, p. 26523 - 26527 (2018/08/07)
A microwave-assisted method has been developed for the synthesis of tri-substituted pyrazoles via direct N-heterocyclization of hydrazines with metal-acetylacetonate and -dibenzylideneacetonate without using any base or additives. Most importantly, the synthesis of 1-aryl-5-phenyl-3-styryl-1H-pyrazoles was achieved in a single step using hydrochloride salt of various phenylhydrazines and this is the first report for direct construction of these molecules. The reaction medium and microwave conditions play a critical role for their selective product formation during the reaction. The present reaction explored the usage of metal-diketonic complexes as reaction substrates providing acetylacetone and dibenzylideneacetone moieties to directly participate in cyclization with hydrazines to form the corresponding pyrazoles in excellent yields. The present protocol introduces the important N-heterocyclic moieties in the final structures, giving the reaction great applications from a medicinal chemistry perspective, particularly in the late stage modification strategies in drug discovery.
