1365989-06-5Relevant academic research and scientific papers
Phosphonium salt-catalysed synthesis of nitriles from in situ activated oximes
Denton, Ross M.,An, Jie,Lindovska, Petra,Lewis, William
, p. 2899 - 2905 (2012)
A metal-free catalytic method for the conversion of aromatic and aliphatic aldoximes to nitriles at room temperature using oxalyl chloride (1.2 equiv) in combination with 5 mol % of triphenylphosphine oxide is reported. Of the many potential pathways leading from oxime to nitrile a manifold involving chlorophosphonium salt-catalysed decomposition of oxime chlorooxalates formed in situ is shown to be operative.
