136607-65-3

Upstream product

• 75-15-0 carbon disulfide 
• 133303-48-7 2-(p-chlorobenzyl)-1-(ethoxycarbonylmethyl)pyridinium bromide 
• 77-78-1 dimethyl sulfate 

Downstream Products

• 138962-26-2 10-(4-Chloro-phenyl)-3-ethyl-[1,3]oxazino[6,5-b]indolizine-2,4-dithione 
• 138962-21-7 10-(4-Chloro-phenyl)-3-methyl-[1,3]oxazino[6,5-b]indolizine-2,4-dithione 
• 138962-30-8 3-Allyl-10-(4-chloro-phenyl)-[1,3]oxazino[6,5-b]indolizine-2,4-dithione 

Relevant academic research and scientific papers

Preparation of new nitrogen-bridged heterocycles. 46. Selective formation of 4(1H)-8,8a-dihydro-1,4-thiazino[3,4,5-cd]indolizinone and (E)- 3-(1,3-oxathiol-2-ylidene)-2(3H)-indolizinone derivatives

The reactions of (Z)-3-[mercapto(methylthio)methylene]-2(3H)- indolizinones with bromoacetonitrile and bromoacetates in the presence of a base gave the corresponding 4(1H)-8,8a-dihydro-1,4-thiazino[3,4,5- cd]indolizinone derivatives, but similar treatment of the same compounds with some phenacyl bromides provided a quite different type of product, (E)-3-(5- aryl-1,3-oxathiol-2-ylidene)-2(3h)-indolizinones, in 12-74% yield with the evolution of methanethiol. Interestingly, the reactions of (Z)-3- [mercapto(phenacylthio)methylene]-2(3H)-indolizinones and iodomethane in the presence of a base did not afford the expected (Z)-3-(5-aryl-1,3-oxathiol-2- ylidene)-2(3H)-indolizinones, but gave only the same (E)-isomers in 22-53% yields. The stereochemistry about the C3-C2' double bond in these 3-(5-aryl- 1,3-oxathiol-2-ylidene)-2(3H)-indolizinones was determined to be (E) by X- ray analysis.

A new synthetic approach to some functionalized cycl[3.2.2]azine derivatives

Dehydrogenation of some ethyl 4-oxo-1H-8,8a-dihydro-1,4-thiazino[3,4,5-cd] indolizine-1-carboxylates with 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) were examined. No simply dehydrogenated products such as 4-oxo-1H-and 4-oxo-8H-1,4-thiazino[3,4,5-cd]