136609-87-5Relevant academic research and scientific papers
Synthesis and biological activities of meribendan and related heterocyclic benzimidazolo-pyridazinones
Jonas, R,Klockow, M,Lues, I,Pruecher, H,Schliep, H J,Wurziger, H
, p. 129 - 140 (2007/10/02)
The synthesis of a new heterocyclic benzimidazolo-pyridazinones is described.The new compounds were evaluated as inotropic agents with 'calcium-sensitizing' effects. 5-Methyl-6--2,3,4,5-tetrahydro-pyridazin-3-one hydrochloride (meribendan) turned out to be the most interesting compound and was chosen for development as a positive inotrope. benzimidazole / calcium sensivity / cardiotonics / inotropes / phosphodiesterase / papillary muscle / pyridazinone
