52240-25-2

Basic information

• Product Name: 4-CHLORO-BETA-METHYL-Y-OXO-BENZENEBUTANOIC ACID
• Synonyms: 4-CHLORO-BETA-METHYL-Y-OXO-BENZENEBUTANOIC ACID;4-CHLORO-B-METHYL-Y-OXO-BENZENEBUTANOIC ACID;3-(4-Chlorobenzoyl)butanoic acid;4-Chloro-methyl-oxo-benzenebutanoic acid;4-(4-chlorophenyl)-3-methyl-4-oxobutanoic acid(SALTDATA: FREE);3-(p-Chlorobenzoyl)butanoic acid;4-(4-Chlorophenyl)-3-methyl-4-oxobutanoic acid;4-(4-Chlorophenyl)-3-methyl-4-oxobutyric Acid
• CAS NO: 52240-25-2
• Molecular Formula: C₁₁H₁₁ClO₃
• Molecular Weight: 226.65624
• EINECS: 610-810-1
• Mol File: 52240-25-2.mol
• Article Data: 5

Chemical Properties

• Melting Point: 82-83℃
• Boiling Point: 407.626 °C at 760 mmHg
• Flash Point: 200.325 °C
• Appearance: /
• Density: 1.277
• Vapor Pressure: 2.24E-07mmHg at 25°C
• Refractive Index: 1.55
• Storage Temp.: 2-8°C
• Solubility: soluble in Methanol
• PKA: 4.46±0.19(Predicted)
• CAS DataBase Reference: 4-CHLORO-BETA-METHYL-Y-OXO-BENZENEBUTANOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CHLORO-BETA-METHYL-Y-OXO-BENZENEBUTANOIC ACID(52240-25-2)
• EPA Substance Registry System: 4-CHLORO-BETA-METHYL-Y-OXO-BENZENEBUTANOIC ACID(52240-25-2)

Safety Data

• Hazardous Substances Data: 52240-25-2(Hazardous Substances Data)

Usage

General Description

4-CHLORO-BETA-METHYL-Y-OXO-BENZENEBUTANOIC ACID, also known as clofibric acid, is a chemical compound used as a lipid-lowering agent to reduce blood lipid levels. It is a derivative of fibric acid and functions as a peroxisome proliferator-activated receptor alpha (PPARα) agonist, which plays a role in regulating lipid metabolism. It works by increasing the breakdown of fatty acids and decreasing the production of triglycerides in the liver. Clofibric acid has been used in the past as a pharmaceutical drug to treat high cholesterol and triglyceride levels, but its use has declined due to safety concerns and the availability of more effective lipid-lowering medications. However, it is still used as a research tool in studying lipid metabolism and PPARα function.

InChI:InChI=1/C11H11ClO3/c1-7(6-10(13)14)11(15)8-2-4-9(12)5-3-8/h2-5,7H,6H2,1H3,(H,13,14)

Synthetic route

4-(4-chlorophenyl)-3-methyl-4-oxobutyronitrile (53012-96-7) → 4-(4-chlorophenyl)-3-methyl-4-oxobutanoic acid (52240-25-2)

Conditions	Yield
With hydrogenchloride; water at 100℃; for 5h; Inert atmosphere;	72%
With hydrogenchloride; water at 100℃; for 5h; Inert atmosphere;	72%
With hydrogenchloride; water Heating;	54.6%
With hydrogenchloride; water

4'-chloropropiophenone (6285-05-8) + lithium-bromoacetate → 4-(4-chlorophenyl)-3-methyl-4-oxobutanoic acid (52240-25-2)

Conditions	Yield

4-chlorobenzaldehyde (104-88-1) → 4-(4-chlorophenyl)-3-methyl-4-oxobutanoic acid (52240-25-2)

Conditions	Yield
Multi-step reaction with 2 steps 1: sodium cyanide / dimethylformamide / 2 h / 40 °C 2: 54.6 percent / conc. HCl, water / Heating View Scheme
Multi-step reaction with 2 steps 1: sodium cyanide / N,N-dimethyl-formamide; methanol 2: hydrogenchloride; water View Scheme
Multi-step reaction with 2 steps 1.1: N,N-dimethyl-formamide / 2 h / 35 - 38 °C / Inert atmosphere 1.2: 3.5 h / 40 °C / Inert atmosphere 2.1: hydrogenchloride; water / 5 h / 100 °C / Inert atmosphere View Scheme
Multi-step reaction with 2 steps 1.1: sodium cyanide / N,N-dimethyl-formamide / 2 h / 35 - 38 °C / Inert atmosphere 1.2: 40 °C / Inert atmosphere 2.1: hydrogenchloride; water / 5 h / 100 °C / Inert atmosphere View Scheme

4-(4-chlorophenyl)-3-methyl-4-oxobutanoic acid (52240-25-2) → 3-methyl-4-oxo-4-(3'-nitro-4'-chloro-phenyl)-butyric acid (85633-96-1)

Conditions	Yield
With nitric acid at -15 - -10℃; for 0.5h;	98%
With nitric acid at -15 - -10℃; Inert atmosphere;	90%
With nitric acid at -15 - -10℃; Inert atmosphere;	90%
With nitric acid In water

4-(4-chlorophenyl)-3-methyl-4-oxobutanoic acid (52240-25-2) → 5-methyl-6-<2-(2-pyrrolyl)-5-benzimidazoyl>-2,3,4,5-tetrahydro-pyridazin-3-one

Conditions	Yield
Multi-step reaction with 5 steps 1: 98 percent / nitric acid / 0.5 h / -15 - -10 °C 2: 98 percent / hydrazine hydrate / acetic acid / 2.5 h / 100 °C 3: 86 percent / butan-1-ol / 20 h / Heating 4: 88.6 percent / H2, 1N aq. HCL / 5percent Pd/C / methanol / 2 h 5: 32 percent / sodium bisulfite / dimethylformamide / 2 h / Heating View Scheme

4-(4-chlorophenyl)-3-methyl-4-oxobutanoic acid (52240-25-2) → 5-methyl-6<2-(2-thiazolyl)-5-benzimidazoyl>-2,3,4,5-tetrahydro-pyridazin-3-one

Conditions	Yield
Multi-step reaction with 5 steps 1: 98 percent / nitric acid / 0.5 h / -15 - -10 °C 2: 98 percent / hydrazine hydrate / acetic acid / 2.5 h / 100 °C 3: 86 percent / butan-1-ol / 20 h / Heating 4: 88.6 percent / H2, 1N aq. HCL / 5percent Pd/C / methanol / 2 h 5: 29 percent / sodium bisulfite / dimethylformamide / 2 h / Heating View Scheme

4-(4-chlorophenyl)-3-methyl-4-oxobutanoic acid (52240-25-2) → 5-methyl-6-<2-(1,2,4-triazol-5-yl)-5-benzimidazoyl>-2,3,4,5-tetrahydro-pyridazin-3-one

Conditions	Yield
Multi-step reaction with 5 steps 1: 98 percent / nitric acid / 0.5 h / -15 - -10 °C 2: 98 percent / hydrazine hydrate / acetic acid / 2.5 h / 100 °C 3: 86 percent / butan-1-ol / 20 h / Heating 4: 88.6 percent / H2, 1N aq. HCL / 5percent Pd/C / methanol / 2 h 5: 25 percent / sodium bisulfite / dimethylformamide / 2 h / Heating View Scheme

4-(4-chlorophenyl)-3-methyl-4-oxobutanoic acid (52240-25-2) → 5-methyl-6-<2-(5-<1-methyl>pyrazolyl)-5-benzimidazoyl>-2,3,4,5-tetrahydro-pyridazin-3-one

Conditions	Yield
Multi-step reaction with 5 steps 1: 98 percent / nitric acid / 0.5 h / -15 - -10 °C 2: 98 percent / hydrazine hydrate / acetic acid / 2.5 h / 100 °C 3: 86 percent / butan-1-ol / 20 h / Heating 4: 88.6 percent / H2, 1N aq. HCL / 5percent Pd/C / methanol / 2 h 5: 68 percent / sodium bisulfite / dimethylformamide / 2 h / Heating View Scheme

4-(4-chlorophenyl)-3-methyl-4-oxobutanoic acid (52240-25-2) → 5-methyl-6-<2-(3-<1-methyl>pyrazolyl)-5-benzimidazoyl>-2,3,4,5-tetrahydro-pyridazin-3-one

Conditions	Yield
Multi-step reaction with 5 steps 1: 98 percent / nitric acid / 0.5 h / -15 - -10 °C 2: 98 percent / hydrazine hydrate / acetic acid / 2.5 h / 100 °C 3: 86 percent / butan-1-ol / 20 h / Heating 4: 88.6 percent / H2, 1N aq. HCL / 5percent Pd/C / methanol / 2 h 5: 54 percent / sodium bisulfite / dimethylformamide / 2 h / Heating View Scheme

4-(4-chlorophenyl)-3-methyl-4-oxobutanoic acid (52240-25-2) → 5-methyl-6-<2-(2-<5-chlorothienyl>)-5-benzimidazoyl>-2,3,4,5-tetrahydro-pyridazin-3-one

Conditions	Yield
Multi-step reaction with 5 steps 1: 98 percent / nitric acid / 0.5 h / -15 - -10 °C 2: 98 percent / hydrazine hydrate / acetic acid / 2.5 h / 100 °C 3: 86 percent / butan-1-ol / 20 h / Heating 4: 88.6 percent / H2, 1N aq. HCL / 5percent Pd/C / methanol / 2 h 5: 35 percent / sodium bisulfite / dimethylformamide / 2 h / Heating View Scheme

4-(4-chlorophenyl)-3-methyl-4-oxobutanoic acid (52240-25-2) → 6-(3,4-diaminophenyl)-5-methyl-2,3,4,5-tetrahydropyridazin-3-one (136609-85-3, 136609-86-4, 74150-02-0)

Conditions	Yield
Multi-step reaction with 4 steps 1: 98 percent / nitric acid / 0.5 h / -15 - -10 °C 2: 98 percent / hydrazine hydrate / acetic acid / 2.5 h / 100 °C 3: 86 percent / butan-1-ol / 20 h / Heating 4: 88.6 percent / H2, 1N aq. HCL / 5percent Pd/C / methanol / 2 h View Scheme
Multi-step reaction with 4 steps 1: nitric acid / water 2: hydrazine hydrate; acetic acid / water 3: butan-1-ol; water 4: hydrogenchloride; hydrogen / palladium on carbon / water; methanol View Scheme
Multi-step reaction with 4 steps 1: nitric acid / -15 - -10 °C / Inert atmosphere 2: hydrazine hydrate; acetic acid / 30 - 100 °C / Inert atmosphere 3: L-proline; sodium carbonate; sodium azide; sodium L-ascorbate; copper(ll) sulfate pentahydrate / dimethyl sulfoxide; water / 24 h / 70 °C / Inert atmosphere 4: sodium hydrogensulfide / water; methanol / 6 h / 65 °C / Inert atmosphere View Scheme
Multi-step reaction with 4 steps 1: nitric acid / -15 - -10 °C / Inert atmosphere 2: acetic acid; hydrazine hydrate / 4.5 h / 30 - 100 °C / Inert atmosphere 3: sodium carbonate; sodium azide; sodium L-ascorbate; L-proline; copper(ll) sulfate pentahydrate / dimethyl sulfoxide; water / 24 h / 70 °C / Inert atmosphere 4: sodium hydrogensulfide / water; methanol / 6 h / 65 °C / Inert atmosphere View Scheme

4-(4-chlorophenyl)-3-methyl-4-oxobutanoic acid (52240-25-2) → (+)-6-(3,4-diaminophenyl)-5-methyl-2,3,4,5-tetrahydro-pyridazin-3-one

Conditions	Yield
Multi-step reaction with 5 steps 1: 98 percent / nitric acid / 0.5 h / -15 - -10 °C 3: hydrazine hydrate / acetic acid / 2.5 h / 100 °C 4: butan-1-ol / 20 h / Heating 5: H2, 1N aq. HCL / 5percent Pd/C / methanol / 2 h View Scheme

4-(4-chlorophenyl)-3-methyl-4-oxobutanoic acid (52240-25-2) → (-)-6-(3,4-diaminophenyl)-5-methyl-2,3,4,5-tetrahydro-pyridazin-3-one

Conditions	Yield
Multi-step reaction with 5 steps 1: 98 percent / nitric acid / 0.5 h / -15 - -10 °C 3: hydrazine hydrate / acetic acid / 2.5 h / 100 °C 4: butan-1-ol / 20 h / Heating 5: H2, 1N aq. HCL / 5percent Pd/C / methanol / 2 h View Scheme

4-(4-chlorophenyl)-3-methyl-4-oxobutanoic acid (52240-25-2) → (+)-4-(4-chloro-3-nitrophenyl)-3-methyl-4-oxobutyric acid (151911-11-4)

Conditions	Yield
Multi-step reaction with 2 steps 1: 98 percent / nitric acid / 0.5 h / -15 - -10 °C View Scheme

4-(4-chlorophenyl)-3-methyl-4-oxobutanoic acid (52240-25-2) → (-)-4-(4-chloro-3-nitrophenyl)-3-methyl-4-oxobutyric acid (136609-87-5)

Conditions	Yield
Multi-step reaction with 2 steps 1: 98 percent / nitric acid / 0.5 h / -15 - -10 °C View Scheme

4-(4-chlorophenyl)-3-methyl-4-oxobutanoic acid (52240-25-2) → 6-(4-chloro-3-nitrophenyl)-5-methyl-2,3,4,5-tetrahydropyridazin-3-one (117397-88-3, 136609-88-6, 151870-45-0)

Conditions	Yield
Multi-step reaction with 2 steps 1: 98 percent / nitric acid / 0.5 h / -15 - -10 °C 2: 98 percent / hydrazine hydrate / acetic acid / 2.5 h / 100 °C View Scheme
Multi-step reaction with 2 steps 1: nitric acid / water 2: hydrazine hydrate; acetic acid / water View Scheme
Multi-step reaction with 2 steps 1: nitric acid / -15 - -10 °C / Inert atmosphere 2: hydrazine hydrate; acetic acid / 30 - 100 °C / Inert atmosphere View Scheme
Multi-step reaction with 2 steps 1: nitric acid / -15 - -10 °C / Inert atmosphere 2: acetic acid; hydrazine hydrate / 4.5 h / 30 - 100 °C / Inert atmosphere View Scheme

4-(4-chlorophenyl)-3-methyl-4-oxobutanoic acid (52240-25-2) → (+)-6-(4-chloro-3-nitrophenyl)-5-methyl-2,3,4,5-tetrahydropyridazin-3-one

Conditions	Yield
Multi-step reaction with 3 steps 1: 98 percent / nitric acid / 0.5 h / -15 - -10 °C 3: hydrazine hydrate / acetic acid / 2.5 h / 100 °C View Scheme

4-(4-chlorophenyl)-3-methyl-4-oxobutanoic acid (52240-25-2) → (-)-6-(4-chloro-3-nitrophenyl)-5-methyl-2,3,4,5-tetrahydropyridazin-3-one

Conditions	Yield
Multi-step reaction with 3 steps 1: 98 percent / nitric acid / 0.5 h / -15 - -10 °C 3: hydrazine hydrate / acetic acid / 2.5 h / 100 °C View Scheme

4-(4-chlorophenyl)-3-methyl-4-oxobutanoic acid (52240-25-2) → 5-methyl-6-<2-(3-thienyl)-5-benzimidazoyl>-2,3,4,5-tetrahydro-pyridazin-3-one

Conditions	Yield
Multi-step reaction with 5 steps 1: 98 percent / nitric acid / 0.5 h / -15 - -10 °C 2: 98 percent / hydrazine hydrate / acetic acid / 2.5 h / 100 °C 3: 86 percent / butan-1-ol / 20 h / Heating 4: 88.6 percent / H2, 1N aq. HCL / 5percent Pd/C / methanol / 2 h 5: sodium bisulfite / dimethylformamide / 2 h / Heating View Scheme

4-(4-chlorophenyl)-3-methyl-4-oxobutanoic acid (52240-25-2) → 5-methyl-6-<2-(2-furyl)-5-benzimidazoyl>-2,3,4,5-tetrahydro-pyridazin-3-one

Conditions	Yield
Multi-step reaction with 5 steps 1: 98 percent / nitric acid / 0.5 h / -15 - -10 °C 2: 98 percent / hydrazine hydrate / acetic acid / 2.5 h / 100 °C 3: 86 percent / butan-1-ol / 20 h / Heating 4: 88.6 percent / H2, 1N aq. HCL / 5percent Pd/C / methanol / 2 h 5: sodium bisulfite / dimethylformamide / 2 h / Heating View Scheme

4-(4-chlorophenyl)-3-methyl-4-oxobutanoic acid (52240-25-2) → 5-methyl-6-<2-(2-thienyl)-5-benzimidazoyl>-2,3,4,5-tetrahydro-pyridazin-3-one

Conditions	Yield
Multi-step reaction with 5 steps 1: 98 percent / nitric acid / 0.5 h / -15 - -10 °C 2: 98 percent / hydrazine hydrate / acetic acid / 2.5 h / 100 °C 3: 86 percent / butan-1-ol / 20 h / Heating 4: 88.6 percent / H2, 1N aq. HCL / 5percent Pd/C / methanol / 2 h 5: sodium bisulfite / dimethylformamide / 2 h / Heating View Scheme

4-(4-chlorophenyl)-3-methyl-4-oxobutanoic acid (52240-25-2) → 5-methyl-6-<2-(4-thiazolyl)-5-benzimidazoyl>-2,3,4,5-tetrahydro-pyridazin-3-one

Conditions	Yield
Multi-step reaction with 5 steps 1: 98 percent / nitric acid / 0.5 h / -15 - -10 °C 2: 98 percent / hydrazine hydrate / acetic acid / 2.5 h / 100 °C 3: 86 percent / butan-1-ol / 20 h / Heating 4: 88.6 percent / H2, 1N aq. HCL / 5percent Pd/C / methanol / 2 h 5: sodium bisulfite / dimethylformamide / 2 h / Heating View Scheme

4-(4-chlorophenyl)-3-methyl-4-oxobutanoic acid (52240-25-2) → 5-methyl-6-<2-(3-pyrazolyl)-5-benzimidazolyl>-2,3,4,5-tetrahydro-pyridazin-3-one

Conditions	Yield
Multi-step reaction with 5 steps 1: 98 percent / nitric acid / 0.5 h / -15 - -10 °C 2: 98 percent / hydrazine hydrate / acetic acid / 2.5 h / 100 °C 3: 86 percent / butan-1-ol / 20 h / Heating 4: 88.6 percent / H2, 1N aq. HCL / 5percent Pd/C / methanol / 2 h 5: 84 percent / sodium bisulfite / dimethylformamide / 2 h / Heating View Scheme

4-(4-chlorophenyl)-3-methyl-4-oxobutanoic acid (52240-25-2) → (-)-5-methyl-6-<2-(3-pyrazolyl)-5-benzimidazoyl>-2,3,4,5-tetrahydro-pyridazin-3-one

Conditions	Yield
Multi-step reaction with 6 steps 1: 98 percent / nitric acid / 0.5 h / -15 - -10 °C 3: hydrazine hydrate / acetic acid / 2.5 h / 100 °C 4: butan-1-ol / 20 h / Heating 5: H2, 1N aq. HCL / 5percent Pd/C / methanol / 2 h 6: sodium bisulfite / dimethylformamide / 2 h / Heating View Scheme

4-(4-chlorophenyl)-3-methyl-4-oxobutanoic acid (52240-25-2) → (+)-5-methyl-6-<2-(3-pyrazolyl)-5-benzimidazoyl>-2,3,4,5-tetrahydro-pyridazin-3-one

Conditions	Yield
Multi-step reaction with 6 steps 1: 98 percent / nitric acid / 0.5 h / -15 - -10 °C 3: hydrazine hydrate / acetic acid / 2.5 h / 100 °C 4: butan-1-ol / 20 h / Heating 5: H2, 1N aq. HCL / 5percent Pd/C / methanol / 2 h 6: sodium bisulfite / dimethylformamide / 2 h / Heating View Scheme

4-(4-chlorophenyl)-3-methyl-4-oxobutanoic acid (52240-25-2) → 5-methyl-6<2-(4-pyrazolyl)-5-benzimidazoyl>-2,3,4,5-tetrahydro-pyridazin-3-one

Conditions	Yield
Multi-step reaction with 5 steps 1: 98 percent / nitric acid / 0.5 h / -15 - -10 °C 2: 98 percent / hydrazine hydrate / acetic acid / 2.5 h / 100 °C 3: 86 percent / butan-1-ol / 20 h / Heating 4: 88.6 percent / H2, 1N aq. HCL / 5percent Pd/C / methanol / 2 h 5: sodium bisulfite / dimethylformamide / 2 h / Heating View Scheme

4-(4-chlorophenyl)-3-methyl-4-oxobutanoic acid (52240-25-2) → 5-methyl-6-<2-(2-<4-bromothienyl>)-5-benzimidazoyl>-2,3,4,5-tetrahydro-pyridazin-3-one

Conditions	Yield
Multi-step reaction with 5 steps 1: 98 percent / nitric acid / 0.5 h / -15 - -10 °C 2: 98 percent / hydrazine hydrate / acetic acid / 2.5 h / 100 °C 3: 86 percent / butan-1-ol / 20 h / Heating 4: 88.6 percent / H2, 1N aq. HCL / 5percent Pd/C / methanol / 2 h 5: sodium bisulfite / dimethylformamide / 2 h / Heating View Scheme

4-(4-chlorophenyl)-3-methyl-4-oxobutanoic acid (52240-25-2) → 5-methyl-6-<2-(2-<5-bromothienyl>)-5-benzimidazoyl>-2,3,4,5-tetrahydro-pyridazin-3-one

Conditions	Yield
Multi-step reaction with 5 steps 1: 98 percent / nitric acid / 0.5 h / -15 - -10 °C 2: 98 percent / hydrazine hydrate / acetic acid / 2.5 h / 100 °C 3: 86 percent / butan-1-ol / 20 h / Heating 4: 88.6 percent / H2, 1N aq. HCL / 5percent Pd/C / methanol / 2 h 5: sodium bisulfite / dimethylformamide / 2 h / Heating View Scheme

4-(4-chlorophenyl)-3-methyl-4-oxobutanoic acid (52240-25-2) → 5-methyl-6-<2-(3-<1,5-dimethyl>-pyrazolyl)-5-benzimidazoyl>-2,3,4,5-tetrahydro-pyridazin-3-one

Conditions	Yield
Multi-step reaction with 5 steps 1: 98 percent / nitric acid / 0.5 h / -15 - -10 °C 2: 98 percent / hydrazine hydrate / acetic acid / 2.5 h / 100 °C 3: 86 percent / butan-1-ol / 20 h / Heating 4: 88.6 percent / H2, 1N aq. HCL / 5percent Pd/C / methanol / 2 h 5: sodium bisulfite / dimethylformamide / 2 h / Heating View Scheme

4-(4-chlorophenyl)-3-methyl-4-oxobutanoic acid (52240-25-2) → 5-methyl-6-[3'-nitro-4'-benzylamino-phenyl]-4,5-dihydro-3(2H)-pyridazinone (77469-62-6, 136609-89-7, 151870-46-1)

Conditions	Yield
Multi-step reaction with 3 steps 1: 98 percent / nitric acid / 0.5 h / -15 - -10 °C 2: 98 percent / hydrazine hydrate / acetic acid / 2.5 h / 100 °C 3: 86 percent / butan-1-ol / 20 h / Heating View Scheme
Multi-step reaction with 3 steps 1: nitric acid / water 2: hydrazine hydrate; acetic acid / water 3: butan-1-ol; water View Scheme
Multi-step reaction with 4 steps 1.1: nitric acid / -15 - -10 °C / Inert atmosphere 2.1: hydrazine hydrate; acetic acid / 30 - 100 °C / Inert atmosphere 3.1: L-proline; sodium carbonate; sodium azide; sodium L-ascorbate; copper(ll) sulfate pentahydrate / dimethyl sulfoxide; water / 24 h / 70 °C / Inert atmosphere 4.1: acetic acid / 0.25 h / Inert atmosphere 4.2: 15.5 h / 10 - 20 °C View Scheme
Multi-step reaction with 4 steps 1.1: nitric acid / -15 - -10 °C / Inert atmosphere 2.1: acetic acid; hydrazine hydrate / 4.5 h / 30 - 100 °C / Inert atmosphere 3.1: sodium carbonate; sodium azide; sodium L-ascorbate; L-proline; copper(ll) sulfate pentahydrate / dimethyl sulfoxide; water / 24 h / 70 °C / Inert atmosphere 4.1: acetic acid / 0.25 h / Inert atmosphere 4.2: 20 h / 10 °C / Inert atmosphere View Scheme

Upstream product

• 3724-65-0 2-butenoic acid 
• 104-88-1 4-chlorobenzaldehyde 
• 6285-05-8 4'-chloropropiophenone 
• 53012-96-7 4-(4-chlorophenyl)-3-methyl-4-oxobutyronitrile 

Downstream Products

• 118428-37-8 pimobendan 
• 77469-62-6 5-methyl-6-[3'-nitro-4'-benzylamino-phenyl]-4,5-dihydro-3(2H)-pyridazinone 
• 117397-88-3 6-(4-chloro-3-nitrophenyl)-5-methyl-2,3,4,5-tetrahydropyridazin-3-one 
• 136609-87-5 (-)-4-(4-chloro-3-nitrophenyl)-3-methyl-4-oxobutyric acid 
• 151911-11-4 (+)-4-(4-chloro-3-nitrophenyl)-3-methyl-4-oxobutyric acid 
• 136609-85-3 6-(3,4-diaminophenyl)-5-methyl-2,3,4,5-tetrahydropyridazin-3-one 
• 85633-96-1 3-methyl-4-oxo-4-(3'-nitro-4'-chloro-phenyl)-butyric acid 

Relevant articles and documents

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