136612-97-0Relevant articles and documents
H-BPin/KOtBu Promoted Activation of Cobalt Salt to a Heterotopic Catalyst for Highly Selective Cyclotrimerization of Alkynes
Song, Shuo,Li, Chuhan,Liu, Tianfen,Zhang, Panke,Wang, Xiaoming
supporting information, p. 6925 - 6930 (2021/09/14)
A mixture of HBPin with KOtBu was found to activate cobalt salt to form a heterotopic cobalt species that is highly active for catalytic intermolecular trimerization of alkynes. This protocol affords 1,2,4-regioisomers in good yields with high regioselectivities under mild conditions. These salient features, together with the operational simplicity and high efficiency, as well as obviating the use of any costly and/or air sensitive ligands, renders the protocol promising for practical applications.
A general protocol for the efficient synthesis of polyarylated benzenes by multiple Suzuki-Miyaura reactions of polychlorinated benzenes
Reimann, Sebastian,Ehlers, Peter,Sharif, Muhammad,Spannenberg, Anke,Langer, Peter
, p. 1083 - 1094 (2016/07/06)
A general protocol for the highly efficient synthesis of polyarylated benzene derivatives by multiple Suzuki-Miyaura reactions of polychlorinated benzenes was developed. Using bulky and electron-rich phosphine ligands, up to quantitative yields of the desired compounds were achieved. Moreover, the reactions show good functional group tolerance and allow the employment of sterically demanding boronic acids.
A practical ruthenium based catalytic system bearing a switchable selectivity between the dimerization and cyclotrimerization reactions of alkynes
?ztürk, Bengi ?zgün,Karabulut, Solmaz,Imamoglu, Yavuz
experimental part, p. 214 - 222 (2012/09/08)
In this study, a practical and inexpensive switchable catalytic system (cyclotrimerization vs. dimerization), [RuCl2(p-cymene)] 2/PR3 has been developed for the catalytic dimerization of terminal alkynes. Bulky and basic phosphine derivatives, PCy3 and P(i-Pr)3, were used with [RuCl2(p-cymene)] 2 and excess of terminal alkyne to in situ formation of vinylidenic intermediates which are active towards dimerization reactions. Effect of phosphine/ruthenium ratio has been investigated. A solvent study was carried out and toluene was found to be the most versatile solvent for both cyclotrimerization and dimerization reactions. A set of aryl and alkyl acetylenes were chosen as substrates to investigate the effect of the nature of the substrates on alkyne dimerization reactions catalyzed by [RuCl 2(p-cymene)]2/PR3. In conclusion, we have shown that [RuCl2(p-cymene)]2/PCy3 can be used as a practical and inexpensive catalytic system which has a switchable selectivity towards cyclotrimerization and dimerization reactions. Best results in means of regioselectivity and yield were observed by using arylacetylene derivatives in these reactions. This catalytic system emerges as an economical method for the transformation of arylacetylenes to corresponding enyne and arene derivatives in excellent yields and selectivity.
