13662-47-0

Upstream product

• 119072-55-8 tert-butylisonitrile 
• 7078-98-0 2,6-di-tert-butyl-4-benzylidene-cyclohexa-2,5-dienone 
• 7677-24-9 trimethylsilyl cyanide 

Downstream Products

• 13662-39-0 4-(2-amino-1-phenylethyl)-2,6-di-tert-butylphenol 
• 39696-82-7 2-(4-hydroxyphenyl)-2-phenylacetonitrile 

Relevant academic research and scientific papers

Accessing α-Arylated Nitriles via BF3·OEt2 Catalyzed Cyanation of para-Quinone Methides Using tert-Butyl Isocyanide as a Cyanide Source

BF3·OEt2 catalyzed 1,6-conjugate addition of tert-butyl isocyanide to para-quinone methides and fuchsones for the synthesis of α-diaryl and α-triaryl nitriles has been reported. This protocol allows α-diaryl- and α-triaryl nitriles to be accessed in good to excellent yields and with a broad substrate scope, which could be further functionalized to give a versatile set of products. This is the first example wherein tert-butyl isocyanide has been used as a cyanide source for the 1,6-conjugate addition.

N-Heterocyclic Carbene Catalyzed 1,6-Conjugate Addition of Me3Si-CN to para-Quinone Methides and Fuchsones: Access to α-Arylated Nitriles

An organocatalytic approach toward α-arylated nitriles using N-heterocyclic carbene (NHC) as a catalyst is described. This protocol comprises an NHC catalyzed activation of Me3Si-CN followed by 1,6-conjugate addition of cyanide to para-quinone methides (p-QMs) and fuchsones leading to α-diaryl- and α-triaryl nitriles in good to excellent yields.