1366233-16-0

Basic information

• Product Name: C₂₃H₂₇N₃O₅S
• CAS NO: 1366233-16-0
• Molecular Weight: 457.55
• Mol File: 1366233-16-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₃H₂₇N₃O₅S(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₃H₂₇N₃O₅S(1366233-16-0)
• EPA Substance Registry System: C₂₃H₂₇N₃O₅S(1366233-16-0)

Safety Data

• Hazardous Substances Data: 1366233-16-0(Hazardous Substances Data)

Upstream product

• 100-06-1 1-(4-methoxyphenyl)ethanone 
• 114570-69-3 3-(2-furyl)-1-(4-methoxyphenyl)propen-1-one 
• 1188265-06-6 7-(4-methoxyphenyl)-4,7-dioxoheptanoic acid ethyl ester 
• 1208318-94-8 1-amino-(2-methyl-4-(sulfamoylamino)phenyl) 
• 98-01-1 furfural 

Downstream Products

• 1208317-19-4 3-(5-(4-methoxyphenyl)-1-(2-methyl-4-(sulfamoylamino)phenyl)-1H-pyrrol-2-yl)propanoic acid 

Relevant articles and documents

Structure-activity relationship of pyrrole based S-nitrosoglutathione reductase inhibitors: Carboxamide modification

The enzyme S-nitrosoglutathione reductase (GSNOR) is a member of the alcohol dehydrogenase family (ADH) that regulates the levels of S-nitrosothiols (SNOs) through catabolism of S-nitrosoglutathione (GSNO). GSNO and SNOs are implicated in the pathogenesis of many diseases including those in respiratory, gastrointestinal, and cardiovascular systems. The pyrrole based N6022 was recently identified as a potent, selective, reversible, and efficacious GSNOR inhibitor which is currently in clinical development for acute asthma. We describe here the synthesis and structure-activity relationships (SAR) of novel pyrrole based analogs of N6022 focusing on carboxamide modifications on the pendant N-phenyl moiety. We have identified potent and novel GSNOR inhibitors that demonstrate efficacy in an ovalbumin (OVA) induced asthma model in mice.