13663-04-2

Basic information

• Product Name: 1-(p-chlorophenylthio)-2-propanol
• Synonyms: 2-Propanol,1-[(p-chlorophenyl)thio]- (8CI)
• CAS NO: 13663-04-2
• Molecular Formula: C₉H₁₁ClOS
• Molecular Weight: 0
• Mol File: 13663-04-2.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 310.8°Cat760mmHg
• Flash Point: 141.8°C
• Appearance: /
• Density: 1.24g/cm³
• Vapor Pressure: 0.000251mmHg at 25°C
• Refractive Index: 1.59
• CAS DataBase Reference: 1-(p-chlorophenylthio)-2-propanol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(p-chlorophenylthio)-2-propanol(13663-04-2)
• EPA Substance Registry System: 1-(p-chlorophenylthio)-2-propanol(13663-04-2)

Safety Data

• Hazardous Substances Data: 13663-04-2(Hazardous Substances Data)

Usage

InChI:InChI=1/C9H11ClOS/c1-7(11)6-12-9-4-2-8(10)3-5-9/h2-5,7,11H,6H2,1H3

Upstream product

• 106-54-7 p-Chlorothiophenol 
• 75-56-9 methyloxirane 
• 25784-83-2 (p-chlorophenylthio)acetone 
• 18803-44-6 sodium p-chlorothiophenolate 
• 1142-19-4 4,4'-dichlorodiphenyl disulfide 

Downstream Products

• 104864-62-2 1-(4-chlorophenylthio)-2-tosyloxypropane 
• 32300-43-9 1-p-Chlorphenylthio-2-mesyloxypropan 

Relevant articles and documents

An efficient catalyst for ring opening of epoxides with phenol and thiophenol under solvent-free conditions

An efficient and rapid procedure for ring opening reaction of various epoxides with phenol and thiophenol derivatives was developed. The procedure can be obtained at room temperature under solvent-free condition in presence of (C4H12N2)2[BiCl6] Cl·H2O (1 mol %). This catalyst can be reused several times without significant loss of activity.

Regioselective reaction of epoxides with disulfides using Zn/AlCl 3 system: A simple synthesis of β-hydroxy sulfides

Epoxides are regioselectively cleaved by zinc thiolate intermediate, generated from disulfides in the presence of Zn/AlCl3 system, to afford high yields of the corresponding β-hydroxy sulfides.

2-(Arylthio)ethanamines and &α-(Arylthio)propionamides with Antidepressant Activity

Reaction of aziridine with thiophenols affords 2-arylthioethanamines; with 2-methylaziridine, ring opening occurs regiospecifically to provide 1-arylthio-2-propanamines.The structure of one member of this group, 1-(4-chlorophenylthio)-2-propanamine (7), has been proved by other unambiguous syntheses. 7 and isomer 12 arise from the alkylation of 4-chlorothiophenol with 2-chloropropylamine as well as from the displacement of the tosyl group in 1-(4-chlorophenylthio)-2-tosyloxypropane (13).Alkylation of 4-chlorothiophenol with α-chloropropionamide affords 11 which leads to 12 on LAH reduction.Ethanamines and propanamines are converted into guanidines, amides, ureas and thioureas.Many arylthioethanamines, e.g. 7, 22, 28, 38 and 39 (as HCl salts) and α-arylthiopropionamides, e.g. 11, 86, 91, 93 and 96 exhibit good activity in the DOPA potentiation and reserpine antagonism tests.Among these, 7 HCl is the most potent and does not inhibit rat brain MAO activity.In clinical trials, C 2998-Go compares favourably with imipramine.