13663-51-9Relevant academic research and scientific papers
Ruthenium-catalyzed reduction of N-alkoxy- and N-hydroxyamides
Fukuzawa, Hiroko,Ura, Yasuyuki,Kataoka, Yasutaka
, p. 3643 - 3648 (2011)
A ruthenium-catalyzed reduction of N-alkoxy- and N-hydroxyamides was found to afford corresponding amides in good to high yields. A simple RuCl 3/Zn-Cu/alcohol system, without the addition of any other ligands, exhibited a high catalytic activity, and therefore the present reaction does not require a stoichiometric amount of metals or metal complexes as reductants. When β-substituted-α,β-unsaturated N-methoxyamides were employed as substrates, concurrent hydrogenation of the olefin moiety proceeded slowly with deprotection of the methoxy group. In the reduction of N-hydroxyamides, the alcoholic solvent was found to function as a hydrogen donor.
