1366422-76-5

Basic information

• Product Name: (R)-4-((2R,3S)-3-((benzyloxy)methyl)oxiran-2-yl)-2,2-dimethyl-1,3-dioxolane
• Synonyms: (R)-4-((2R,3S)-3-((benzyloxy)methyl)oxiran-2-yl)-2,2-dimethyl-1,3-dioxolane
• CAS NO: 1366422-76-5
• Molecular Weight: 264.321
• Mol File: 1366422-76-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (R)-4-((2R,3S)-3-((benzyloxy)methyl)oxiran-2-yl)-2,2-dimethyl-1,3-dioxolane(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-4-((2R,3S)-3-((benzyloxy)methyl)oxiran-2-yl)-2,2-dimethyl-1,3-dioxolane(1366422-76-5)
• EPA Substance Registry System: (R)-4-((2R,3S)-3-((benzyloxy)methyl)oxiran-2-yl)-2,2-dimethyl-1,3-dioxolane(1366422-76-5)

Safety Data

• Hazardous Substances Data: 1366422-76-5(Hazardous Substances Data)

Upstream product

• 15186-48-8 2,3-isopropylidene-glyceraldehyde 
• 80581-19-7 ((2S,3R)-3-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)oxiran-2-yl)methanol 
• 100-39-0 benzyl bromide 
• 64520-58-7 ethyl (E)-3-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)acrylate 
• 1707-77-3 1,2:5,6-di-O-isopropylidene-D-mannitol 

Downstream Products

• 1366423-18-8 ((2R,3S,4S)-3-(benzyloxy)-4-(benzyloxymethyl)-1-nonylazetidin-2-yl)methanol 
• 1366422-84-5 (2R,3R,4S)-3-(benzyloxy)-2-(benzyloxymethyl)-4-((tertbutyldimethylsilyloxy)methyl)azetidine 
• 1366422-82-3 N-((2R,3R,4R)-1,3-bis(benzyloxy)-5-(tert-butyldimethylsilyloxy)-4-hydroxypentan-2-yl)-4-methylbenzenesulfonamide 
• 1366422-80-1 N-((1R,2R)-1,3-bis(benzyloxy)-1-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)propan-2-yl)-4-methylbenzenesulfonamide 
• 1366422-78-7 (R)-4-((1R,2R)-2-azido-1,3-bis(benzyloxy)propyl)-2,2-dimethyl-1,3-dioxolane 
• 99884-20-5 C₁₅H₂₁N₃O₄ 

Relevant articles and documents

Stereocontrolled Synthesis of Tetrafluoropentanols: Multivicinal Fluorinated Alkane Units for Drug Discovery

A stereodivergent synthesis of four diastereomeric 2,3,4,5-tetrafluoropentanols is disclosed. X-ray crystallographic analysis reveals conformations that manifest sequential stereoelectronic gauche effects (σC-H/C → σC-F*), thereby generating topological diversity via subtle C(sp3)-H to C(sp3)-F exchange. Two representative tetrafluoro arrays have been incorporated into truncated analogues of Gilenya for the management of relapsing remitting multiple sclerosis. These closely similar multivicinal fluoroalkanes have notably different physicochemical profiles and were found to be stable in the presence of human microsomes.