136723-80-3

Basic information

• Product Name: 4-deoxy-4-allyl-(epi)-podophyllotoxin
• Synonyms: 4-deoxy-4-allyl-(epi)-podophyllotoxin
• CAS NO: 136723-80-3
• Molecular Weight: 438.477
• Mol File: 136723-80-3.mol

Chemical Properties

• CAS DataBase Reference: 4-deoxy-4-allyl-(epi)-podophyllotoxin(CAS DataBase Reference)
• NIST Chemistry Reference: 4-deoxy-4-allyl-(epi)-podophyllotoxin(136723-80-3)
• EPA Substance Registry System: 4-deoxy-4-allyl-(epi)-podophyllotoxin(136723-80-3)

Safety Data

• Hazardous Substances Data: 136723-80-3(Hazardous Substances Data)

Upstream product

• 762-72-1 allyl-trimethyl-silane 
• 4375-07-9 epipodophyllotoxin 
• 518-28-5 podofilox 

Downstream Products

• 136755-67-4 1-β-propyl-1-desoxypodophyllotoxin 
• 183986-28-9 3-[(5S,5aR,8aR,9R)-8-Oxo-9-(3,4,5-trimethoxy-phenyl)-5,5a,6,8,8a,9-hexahydro-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl]-propionic acid 
• 183986-26-7 (5R,5aR,8aR,9S)-9-(3-Hydroxy-propyl)-5-(3,4,5-trimethoxy-phenyl)-5,8,8a,9-tetrahydro-5aH-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6-one 

Relevant articles and documents

The Catalytically Lignan-Activation-Based Approach for the Synthesis of (epi)-Podophyllotoxin Derivatives

Under the effect of a catalytic amount of Au(I) complex, 4-O-(2-cyclopropylethynyl)benzoyl-(epi)-podophyllotoxins, easily prepared via dehydrative condensation between (epi)-podophyllotoxin and ortho-cyclopropylethynylbenzoic acid, could efficiently coupl

Preparation method of podophyllotoxin 4-OH derivative

The invention provides a preparation method of a podophyllotoxin 4-OH derivative. A podophyllotoxin 4-OH derivative 1 shown in the specification can be prepared from a compound 2 and a compound 3 through glycosylation , wherein R1 is a common hydroxyl pro

Synthesis and biological evaluation of carbon-substituted C-4 derivatives of podophyllotoxin

Several C-4 carbon-substituted analogues of podophyllotoxin, 1, were prepared by treatment of 1 with allyltrimethylsilane or trimethylsilylcyanide in the presence of boron trifluoride etherate. Alternatively, carbon substituents were introduced via additions to the carbobenzyloxy-protectd C-4'-dimethylated podophyllotoxone. These 4'-dimethylated derivatives showed promising in vitro antitumour activity and were equally active against human colon cell line HT116 and two multidrug resistant cell lines. The alcohol 6 was evaluated in vivo but was found to be inactive. Several C-4 carbon-substituted analogues of podophyllotoxin, 1, were prepared by treatment of 1 with allyltrimethylsilane or trimethylsilylcyanide in the presence of boron trifluoride etherate. Alternatively, carbon substituents were introduced via additions to the carbobenzyloxy-protected C-4′-dimethylated podophyllotoxone. These 4′-dimethylated derivatives showed promising in vitro antitumour activity and were equally active against human colon cell line HT116 and two multidrug resistant cell lines. The alcohol 6 was evaluated in vivo but was found to be inactive.

Antitumor agents. II: Regio- and stereospecific syntheses of 1-β-alkyl-1-desoxypodophyllotoxin derivatives and biological activity

1-β-Alkyl derivatives of 1-desoxypodophyllotoxin were synthesized, and their cytotoxicity and inhibitory effects on DNA topoisomerase II (Topo-II) and tubulin polymerization were examined. The reaction of epipodophyllotoxin derivatives (1a-c) with trimeth