136755-67-4Relevant academic research and scientific papers
Antitumor agents. II: Regio- and stereospecific syntheses of 1-β-alkyl-1-desoxypodophyllotoxin derivatives and biological activity
Terada,Fujimoto,Nomura,Yamashita,Wierzba,Kobunai,Takeda,Minami,Yoshida,Yamaguchi,Yamada
, p. 907 - 912 (1993)
1-β-Alkyl derivatives of 1-desoxypodophyllotoxin were synthesized, and their cytotoxicity and inhibitory effects on DNA topoisomerase II (Topo-II) and tubulin polymerization were examined. The reaction of epipodophyllotoxin derivatives (1a-c) with trimeth
