136725-53-6

Basic information

• Product Name: (R)-(-)-3-FLUOROPYRROLIDINE HYDROCHLORIDE
• Synonyms: (S)-3-FLUORO-PYRROLIDINE HCL;(S)-(+)-3-FLUOROPYRROLIDINE HYDROCHLORIDE;(S)-3-FLUOROPYRROLIDINE HYDROCHLORIDE;(R)-3-FLUORO-PYRROLIDINE HCL;S-(+)-3-Fluoropyrrolidinehydrochloride98%ee;3(S)-fluoropyrrolidine(HCl);(3S)-(+)-3-Fluoropyrrolidine hydrochloride;(S)-3-Fluoropyrrolidine h...
• CAS NO: 136725-53-6
• Molecular Formula: C4H9ClFN
• Molecular Weight: 125.57
• Product Categories: Pyrrolidines;Chiral Building Blocks;Heterocyclic Building Blocks;Asymmetric Synthesis;Building Blocks;Chemical Synthesis;Chiral Building Blocks;Fluorinated Building Blocks;Heterocyclic Building Blocks;Heterocyclic Fluorinated Building Blocks;Other Fluorinated Heterocycles
• Mol File: 136725-53-6.mol
• Article Data: 19

Chemical Properties

• Melting Point: 183-187 °C(lit.)
• Boiling Point: 143.8 °C at 760 mmHg
• Flash Point: 40.8 °C
• Appearance: White to pale brown/Powder or Crystalline Powder
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: (R)-(-)-3-FLUOROPYRROLIDINE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-(-)-3-FLUOROPYRROLIDINE HYDROCHLORIDE(136725-53-6)
• EPA Substance Registry System: (R)-(-)-3-FLUOROPYRROLIDINE HYDROCHLORIDE(136725-53-6)

Safety Data

• Hazard Codes: Xn,Xi
• Statements: 22-36/37/38
• Safety Statements: 26
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 136725-53-6(Hazardous Substances Data)

Usage

Chemical Properties

Light pink to purple solid

Uses

Different sources of media describe the Uses of 136725-53-6 differently. You can refer to the following data:
1. (S)-(+)-3-Fluoropyrrolidine, HCl
2. (S)-(+)-3-Fluoropyrrolidine hydrochloride can be employed as a building block for the preparation of: Fluorinated pyrrolidine derivatives of cyclohexylglycine amides as potential inhibitors for dipeptidyl peptidase IV. Fluoropyrrolidine contaning N--ethylurea pyrazole derivatives as potential and selective inhibitors for Trypanosoma brucei and Trypanosoma cruzi parasitic causative agents. Urea derivatives of (S)-2-(3,4-difluorophenyl)-5-(3-fluoro-N-pyrrolidylamido)benzothiazole as potent antitrypanosomal agents.
3. The derived amide acts as an inhibitor of dipeptidyl peptidase IV.1

InChI:InChI:1S/C4H8FN.ClH/c5-4-1-2-6-3-4;/h4,6H,1-3H2;1H

Upstream product

• 518063-52-0 tert-butyl 3-fluoropyrrolidine-1-carboxylate 
• 136725-54-7 (3S)-3-fluoropyrrolidine 
• 479253-00-4 tert-butyl (S)-3-fluoropyrrolidine-1-carboxylate 
• 136725-52-5 (S)-N-CBz-3-fluoropyrrolidine 
• 876617-25-3 (R)-1-N-tert-butoxycarbonyl-3-fluoropyrrolidine 

Downstream Products

• 1443744-72-6 (R)-7-amino-4-(3-fluoropyrrolidine-1-carbonyl)-2-(4-methoxyphenyl)thieno[3,4-d]pyridazin-1(2H)-one 
• 1443744-73-7 (S)-7-amino-4-(3-fluoropyrrolidine-1-carbonyl)-2-(4-methoxyphenyl)thieno[3,4-d]pyridazin-1(2H)-one 
• 1411774-27-0 (R)-3-fluoropyrrolidine-1-sulfonyl chloride 

Relevant articles and documents

A fluorine-substituted pyrrolidinium-based ionic liquid for high-voltage Li-ion batteries

A fluorine-substituted ionic liquid based on a pyrrolidinium cation and a bis(fluorosulfonyl)imide anion was synthesized using a facile one-step reaction. The resulting ionic liquid is highly pure and when dissolved with LiFSI, the IL-based electrolyte sh

IONIC LIQUID ELECTROLYTE FOR LITHIUM-ION BATTERIES

The ionic liquids disclosed herein are salts comprising a nitrogen or phosphorus such as a quaternary ammonium ion, a quaternary phosphonium ion, or an N-alkylated nitrogen heterocycle, and which include at least one functional substituent, e.g., a fluoro, cyano, carbonate ester, an alkenyl group, or an alkynyl group bonded to a carbon atom the cation. In a preferred embodiment, the cation is represented by the structure of Formula (I) as described herein.

KRAS G12C INHIBITORS

The present invention relates to compounds that inhibit KRas G12C. In particular, the present invention relates to compounds that irreversibly inhibit the activity of KRas G12C, pharmaceutical compositions comprising the compounds and methods of use therefor.