518063-52-0

Basic information

• Product Name: 1-Boc-3-fluoropyrrolidine
• Synonyms: tert-butyl 3-fluoropyrrolidine-1-carboxylate;3-Fluoro-1-pyrrolidinecarboxylic acid tert-butyl ester;N-tert-Butoxycarbonyl-3-fluoropyrrolidine
• CAS NO: 518063-52-0
• Molecular Formula: C₉H₁₆FNO₂
• Molecular Weight: 189.2272432
• Mol File: 518063-52-0.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 230℃
• Flash Point: 93℃
• Appearance: /
• Density: 1.08
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1-Boc-3-fluoropyrrolidine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Boc-3-fluoropyrrolidine(518063-52-0)
• EPA Substance Registry System: 1-Boc-3-fluoropyrrolidine(518063-52-0)

Safety Data

• Hazardous Substances Data: 518063-52-0(Hazardous Substances Data)

Usage

General Description

1-Boc-3-fluoropyrrolidine is a chemical compound that is commonly used in organic synthesis and pharmaceutical research. It is a derivative of pyrrolidine, which is a heterocyclic organic compound. The "Boc" in its name stands for tert-butoxycarbonyl, which is a protective group commonly used in organic chemistry to protect amines from unwanted reactions. The addition of the fluorine atom to the pyrrolidine ring confers unique chemical and biological properties to the compound, making it valuable in drug discovery and development. 1-Boc-3-fluoropyrrolidine is used as a building block in the synthesis of various drug candidates and other biologically active molecules. Its unique structure and properties make it a valuable tool in medicinal and synthetic chemistry.

Upstream product

• 103057-44-9 N-(tert-butoxycarbonyl)-3-hydroxypyrrolidine 
• 1312712-22-3 C₁₅H₂₈BNO₄ 
• 86953-79-9 tert-butyl pyrrolidine-1-carboxylate 
• 939793-16-5 3-bromopyrrolidine-1-carboxylic acid tert-butyl ester 
• 109431-87-0 (R)-tert-butyl 3-hydroxypyrrolidine-1-carboxylate 

Downstream Products

• 136725-53-6 3-fluoropyrrolidine hydrochloride 
• 136725-53-6 3-fluoro-pyrrolidine dihydrochloride 

Relevant articles and documents

Halogen-substituted latrotinib compound

The invention relates to a halogen-substituted latrotinib compound. The halogen-substituted latrotinib compound comprises a latrotinib bisulfate compound labeled by a radioactive halogen atom or a non-radioactive halogen atom. The compound comprises a (R,

Diverse functionalization of strong alkyl C–H bonds by undirected borylation

The selective functionalization of strong, typically inert carbon-hydrogen (C–H) bonds in organic molecules is changing synthetic chemistry. However, the undirected functionalization of primary C–H bonds without competing functionalization of secondary C–H bonds is rare. The borylation of alkyl C–H bonds has occurred previously with this selectivity, but slow rates required the substrate to be the solvent or in large excess. We report an iridium catalyst ligated by 2-methylphenanthroline with activity that enables, with the substrate as limiting reagent, undirected borylation of primary C–H bonds and, when primary C–H bonds are absent or blocked, borylation of strong secondary C–H bonds. Reactions at the resulting carbon-boron bond show how these borylations can lead to the installation of a wide range of carbon-carbon and carbon-heteroatom bonds at previously inaccessible positions of organic molecules.

KRAS G12C INHIBITORS

The present invention relates to compounds that, inhibit KRas G12C, In particular, the present invention relates to compounds that irreversibly inhibit the activity of KRas G12C, pharmaceutical compositions comprising the compounds and methods of use therefor.