1367455-68-2

Upstream product

• 1228311-57-6 [2-amino-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)quinazolin-4-yl]-(1,3-dihydroisoindol-2-yl)methanone 
• 59142-68-6 2-bromo-4-fluorobenzaldehyde 
• 1101145-49-6 (2-amino-6-iodoquinazolin-4-yl)-(1,3-dihydroisoindol-2-yl)methanone 
• 1101147-31-2 tert-butyl {2-[2-(1,3-dihydroisoindol-2-yl)-2-oxoacetyl]-4-iodophenyl}carbamate 
• 1228311-56-5 tert-butyl 5-iodo-2,3-dioxo-2,3-dihydroindole-1-carboxylate 
• 20780-76-1 5-iodoisatin 

Downstream Products

• 1367454-68-9 {2-amino-6-[5-fluoro-2-(4-methylpiperazin-1-ylmethyl)phenyl]quinazolin-4-yl}-(1,3-dihydroisoindol-2-yl)methanone 
• 1367454-37-2 (2-amino-6-{2-[(ethylmethylamino)methyl]-5-fluorophenyl}quinazolin-4-yl)-(1,3-dihydroisoindol-2-yl)methanone 
• 1367454-41-8 [2-amino-6-(2-{[ethyl-(2-hydroxyethyl)amino]methyl}-5-fluorophenyl)quinazolin-4-yl]-(1,3-dihydroisoindol-2-yl)methanone 
• 1367454-46-3 {2-amino-6-[2-(tert-butylaminomethyl)-5-fluorophenyl]-quinazolin-4-yl}-(1,3-dihydroisoindol-2-yl)methanone 
• 1367454-62-3 {2-amino-6-[5-fluoro-2-(2-methylpyrrolidin-1-ylmethyl)phenyl]quinazolin-4-yl}-(1,3-dihydroisoindol-2-yl)methanone 

Relevant academic research and scientific papers

PHENYLQUINAZOLINE DERIVATIVES

Novel quinazolinamide derivatives of the formula (I), in which R1-R43 and X have the meanings indicated in claim 1, are HSP90 inhibitors and can be used for the preparation of a medicament for the treatment of diseases in which the inhibition, regulation and/or modulation of HSP90 plays a role.