136749-80-9

Basic information

• Product Name: 8a-ethyltetrahydro-2H-Pyrrolo[2,1-b][1,3]oxazin-6(7H)-one
• Synonyms: 8a-ethyltetrahydro-2H-Pyrrolo[2,1-b][1,3]oxazin-6(7H)-one
• CAS NO: 136749-80-9
• Molecular Formula: C9H15NO2
• Molecular Weight: 169.2209
• Mol File: 136749-80-9.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 8a-ethyltetrahydro-2H-Pyrrolo[2,1-b][1,3]oxazin-6(7H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 8a-ethyltetrahydro-2H-Pyrrolo[2,1-b][1,3]oxazin-6(7H)-one(136749-80-9)
• EPA Substance Registry System: 8a-ethyltetrahydro-2H-Pyrrolo[2,1-b][1,3]oxazin-6(7H)-one(136749-80-9)

Safety Data

• Hazardous Substances Data: 136749-80-9(Hazardous Substances Data)

Upstream product

• 3249-33-0 ethyl 4-oxohexanoate 
• 156-87-6 propan-1-ol-3-amine 

Relevant articles and documents

Synthesis of (+/-)-6-Alkyl-5-oxa-1-azabicyclononan-9-ones, (+/-)-5-Alkyl-4-oxa-1-azabicyclooctan-8-ones, and Substituted 1,6-Dioxa-3,8-diazacyclodecanes by Reaction of Ethyl 4-Oxoalkanoates with 3-Aminopropanol and 2-Aminoethanol

Ethyl 4-oxoalkanoates 1 react at ambient temperature in dry methanol in the presence of molecular sieve 3 Angstroem in almost quantitative yield with 3-aminopropanol and 2-aminoethanol to form the bicyclic lactams rac-2 and rac-3, respectively.Surprisingly, the (+/-)-5-alkyl-4-oxa-1-azabicyclooctan-8-ones rac-3a-d dimerize in trichloromethane saturated with 2 N HCl to the ten-membered heterocycles 4a-d.The structures of the substituted 1,6-dioxa-3,8-diazacyclodecanes 4a and 4c have been determined by an X-ray crystal analysis. Key Words: 4-Oxoalkanoates, ethyl- / 5-Oxa-1-azabicyclononan-9- ones, (+/-)-6-alkyl- / 4-Oxa-1-azabicyclo-octan-8-ones, (+/-)-5-alkyl- / 1,6-Dioxa-3,8-diazacyclodecanes