136758-25-3

Upstream product

• 606-23-5 1H-indene-1,3(2H)-dione 
• 454-89-7 3-Trifluoromethylbenzaldehyde 

Downstream Products

• 136758-33-3 2-Morpholin-4-yl-5-oxo-4-(3-trifluoromethyl-phenyl)-4,5-dihydro-indeno[1,2-b]pyran-3-carbonitrile 
• 136758-30-0 5-Oxo-2-piperidin-1-yl-4-(3-trifluoromethyl-phenyl)-4,5-dihydro-indeno[1,2-b]pyran-3-carboxylic acid methyl ester 

Relevant academic research and scientific papers

Palladium-Catalyzed Asymmetric [3+2] Cycloaddition of Vinylethylene Carbonates with 2-Arylidene-1,3-Indandiones: Synthesis of Tetrahydrofuran-Fused Spirocyclic 1,3-Indandiones

An asymmetric [3+2] cycloaddition of 2-arylidene-1,3-indandiones with vinylethylene carbonates (VECs) had been achieved in the presence of Pd2dba3·CHCl3 and axially chiral phosphoramidite ligand. The reaction of various su

Benzylidine indane-1,3-diones: As novel urease inhibitors; synthesis, in vitro, and in silico studies

Current study deals with the evaluation of indane-1,3-dione based compounds as new class of urease inhibitors. For that purpose, benzylidine indane-1,3-diones (1–30) were synthesized and fully characterized by different spectroscopic techniques including

Synthesis of spiroindene-1,3-dione isothiazolines via a cascade michael/1,3-dipolar cycloaddition reaction of 1,3,4-oxathiazol-2-one and 2-arylidene-1,3-indandiones

The reaction of 1,3,4-oxathiazol-2-one derivative with 2-arylidene-1,3-indandione to furnish novel spiroindene-1,3-dione isothiazoline derivatives by Michael/1,3-dipolar [3+2]-cycloaddition reaction was investigated. The key 1,3-dipolar cycloaddition reaction step was examined in toluene solvent at reflux temperature to obtain mixture of two regioisomers (6a and 6b – 14a and 14b) and single isomers (15–20). The scope of this new reaction was demonstrated with many examples with high reactivity and yields.

Use of Functionalised Ynamines in a Hetero-Diels-Alder Approach to Dihydronaphtholpyrans and Indenopyrans

Reaction of the ynamine ester methyl 3-(pyrrolidin-1-yl)prop-2-ynoate 5 with 2-(4-nitrobenzylidene)-1-tetralone 1 results in a very poor yield of the chromatographically labile 4-aryl-5,6-dihydro-4H-naphtholpyran 8 along with the α-pyrone 10.Increa

A convient route to polyfunctionalised indeno[1,2-b]pyran derivatives

2-Arylidene-1,3-indanediones undrgo facile formal hetero-Diels-Alder cycloadditions with ynamines bearing electron-withdrawing groups yielding polyfunctionalised indeno[1,2-b]pyrans.