136773-56-3Relevant academic research and scientific papers
Nitriles in Heterocyclic Synthesis: Synthesis of Pyrazolopyrimidine, Pyrazolotriazine and Pyrazolotriazine Derivatives
Elagamey, Abdel Ghani Ali,El-Taweel, Fathy Mohamed Abdel-Aziz
, p. 333 - 338 (2007/10/02)
5-Amino-3-phenylpyrazole (1) reacted with enaminonitriles 2a-c to afford the pyrazolopyrimidines 5a,b and the 5-substituted aminopyrzole 8. 5a reacted with arenediazonium chlorides and benzaldehyde to give 6 and 7 respectively.Also, o-hydroxyacetophenone afforded the fused pyrazole derivative 9 on treatment with 1.Enaminonitrile 3 coupled with 11 and arenediazonium chlorides to give 12 and 13 respectively.Cyclization of 13a,b afforded the pyrazolotriazines 15a,b.
