136773-71-2Relevant academic research and scientific papers
Highly diastereoselective synthesis of 3-methylenetetrahydropyrans by palladium-catalyzed oxa-[4 + 2] cycloaddition of 2-alkenylbenzothiazoles
Ni, Qijian,Song, Xiaoxiao,Xu, Lei
supporting information, p. 6617 - 6621 (2020/09/21)
A highly diastereoselective synthesis of 3-methylenetetrahydropyrans via palladium-catalyzed oxa-[4 + 2] cycloaddition of 2-alkenylbenzothiazoles with allyl carbonates bearing a nucleophilic alcohol side chain is presented. This synthetic methodology tolerates a wide variety of 2-alkenylbenzothiazoles and afforded the desired 3-methylenetetrahydropyrans in good yields and excellent dr. In addition, further derivatizations resulted in new scaffolds, making them useful synthetic precursors.
STUDIES ON 2-SUBSTITUTED METHYLAZOLES: NOVEL SYNTHESIS OF 6-(N-PIPERIDINYL) AND 6-(N-MORPHOLINYL)-1,4-DIHYDROPYRIDINE DERIVATIVES INCORPORATING BENZIMIDAZOLE MOIETY WITH ANTICIPATED BIOLOGICAL ACTIVITY
Nawwar, Galal A. M.,Zohdi, Hussein F.,Swellem, Randa H.,Osman, Soad A.
, p. 457 - 464 (2007/10/02)
The reaction of 2-(2-benzimidazoyl)acetonitrile with 3-(2-hydroxyaryl)propenones (2) in the presence of three equivalents of bases afforded the titled ring systems.When 2-(2-benzothiazolyl)acetonitrile was used instead of 2-(2-benzimidazolyl)acetonitrile
UNCATALYZED KNOEVENAGEL CONDENSATION OF 2-CYANOMETHYLBENZOTHIAZOLE WITH AROMATIC ALDEHYDES. PREPARATION OF 3-ARYL-2-(2-BENZOTHIAZOLYL)-ACRYLONITRILES AND 3-(2-BENZOTHIAZOLYL)-COUMARIN IMINES
Dryanska, Veneta
, p. 325 - 329 (2007/10/02)
A series of 3-aryl-2-(2-benzothiazolyl)-acrylonitriles (3a-n) and 3-(2-benzothiazolyl)-coumarin imines (5a-f) are prepared in good to high yields by refluxing solutions of 2-cyanomethylbenzothiazole (1) and aromatic aldehydes (2, 4) in ethanol. Key words:
