136781-90-3Relevant academic research and scientific papers
Regioselective alkylation of β-cyclodextrin
Bansal, Paramjit S.,Francis, Craig L.,Hart, Noel K.,Henderson, Scott A.,Oakenfull, David,Robertson, Alan D.,Simpson, Gregory W.
, p. 915 - 923 (2007/10/03)
Methodology for preparation of heptakis(2,6-di-O-alkyl)-β-cyclodextrins, heptakis(2-O-alkyl)-β-cyclodextrins, and heptakis(6-O-alkyl)-β-cyclodextrins in substantially purified form has been developed. Treatment of β-cyclodextrin (1) with sodium or barium
Synthesis and characterisation of some lipophilic per(2,6-di-O-alkyl)cyclomalto-oligosaccharides
Wenz, Gerhard
, p. 257 - 266 (2007/10/02)
Cyclomalto-hexa-, -hepta-, and -octa-ose (cyclodextrins; α-, β-, and γ-CD) were alkylated severally using propyl, butyl, pentyl, 3-methylbutyl, and dodecyl bromides and NaOH in methyl sulfoxide at 23 deg C.After reaction for 3-9 days, the per(2,6-di-O-alkyl)-CDs were formed.The regiospecifity of these alkylations was higher than for methylations.The best yields of crystalline products were obtained for the butyl derivatives of α- and β-CD (37percent and 41percent, respectively).The homogeneity of the pattern of substitution was verified by degradation analysis, f.a.b.-m.s., and n.m.r. spectroscopy.
