136786-70-4

Basic information

• Product Name: 5-phenyl-3-thiophen-2-yl-4,5-dihydro-1H-pyrazole
• Synonyms: 5-phenyl-3-thiophen-2-yl-4,5-dihydro-1H-pyrazole
• CAS NO: 136786-70-4
• Molecular Weight: 228.318
• Mol File: 136786-70-4.mol

Chemical Properties

• CAS DataBase Reference: 5-phenyl-3-thiophen-2-yl-4,5-dihydro-1H-pyrazole(CAS DataBase Reference)
• NIST Chemistry Reference: 5-phenyl-3-thiophen-2-yl-4,5-dihydro-1H-pyrazole(136786-70-4)
• EPA Substance Registry System: 5-phenyl-3-thiophen-2-yl-4,5-dihydro-1H-pyrazole(136786-70-4)

Safety Data

• Hazardous Substances Data: 136786-70-4(Hazardous Substances Data)

Upstream product

• 3988-77-0 3-phenyl-1-thiophen-2-yl-propenone 
• 88-15-3 2-Acetylthiophene 
• 100-52-7 benzaldehyde 

Downstream Products

• 37868-91-0 5-phenyl-3-thiophen-2-yl-4,5-dihydro-pyrazole-1-carboxylic acid ethylamide 
• 1106757-75-8 1-N-ethylthiocarbamoyl-3-(2-thienyl)-5-phenyl-2-pyrazoline 
• 1106757-79-2 1-N-phenylthiocarbamoyl-3-(2-thienyl)-5-phenyl-2-pyrazoline 
• 1106757-73-6 1-N-methylthiocarbamoyl-3-(2-thienyl)-5-phenyl-2-pyrazoline 
• 1106757-76-9 1-N-allylthiocarbamoyl-3-(2-thienyl)-5-phenyl-2-pyrazoline 
• 496806-30-5 C₂₀H₁₆N₂OS 
• 21985-07-9 5-phenyl-3-(2′-thienyl)-1H-pyrazole 
• 1366019-65-9 C₁₅H₁₂N₂OS 
• 1366019-92-2 C₂₀H₁₄N₂OS 
• 1262757-93-6 C₁₃H₁₁N₃OS 
• 1366020-19-0 C₁₃H₉N₃OS 
• 680605-83-8 1-(5-phenyl-3-(thiophen-2-yl)-4,5-dihydro-1H-pyrazol-1-yl)ethanone 

Relevant articles and documents

Synthesis of 3,5-disubstituted pyrazoles and their derivatives

2-Acetylthiophene condenses with different aromatic aldehyde in ethanol in the presence of aqueous NaOH to give 1-(2′-thienyl)-3-(substituted phenyl)-2-propen-1-one (Ia-e) which reacts with hydrazine hydrate in ethanol to give pyrazoline (IIa-e) and also treated with DMSO in presence of catalytic amount of iodine to give pyrazole (II′a-e) Similarly, 1-phenyl pyrazoline (IIIa-e) treated with DMSO/I2 to give 1-phenyl pyrazole(III′a- e), 1-(2,4-dinitro phenyl) pyrazoline (IVa-e) treated with DMSO/I2 to give 1-(2,4-dinitro phenyl) pyrazole(IV′a-e), 1-carboxamido pyrazoline (Va-e) treated with DMSO/I2 to give 1-carboxamido pyrazole (V′a-e), 1-acetyl pyrazoline (VIa-e) treated with DMSO/I2 to give 1-acetyl pyrazole (VI′a-e), 1-benzoyl pyrazoline (VIIa-e) treated with DMSO/I2 to give 1-benzoyl pyrazole (VII′a-e) and 1-nitroso pyrazoline (VIIIa-e) treated with DMSO/I2 to give 1-nitroso pyrazole (VIII′a-e). Characterization and structural elucidation was carried out on the basis of melting points determination, analytical and spectral studies.

New pyrazoline derivatives and their antidepressant activity

Some triazolo-pyrazoline derivatives were synthesized to investigate their potential antidepressant activities. The chemical structures of the compounds were elucidated by IR, NMR and FAB+-MS spectral data and elemental analyses. Antidepressant-like activities of the test compounds (100 mg/kg) were screened using both modified forced swimming and tail suspension tests. Rota-Rod test was performed for the examination of probable neurological deficits due to the test compounds, which may interfere with the test results. The test compounds in the series exhibited different levels of antidepressant activities when compared to reference drug fluoxetine. None of the test compounds changed motor coordination of animals when assessed in the Rota-Rod test. Therefore, experimental results in this study were not interfered with motor abnormalities. The study supports the antidepressant-like activities of various pyrazoline and/or triazole derivatives and suggests a possible serotonin related mechanism of action for the tested compounds.

Synthesis and studies on antidepressant and anticonvulsant activities of some 3-(2-thienyl)pyrazoline derivatives

In this study, the synthesis of twelve 3-(2-thienyl)pyrazoline derivatives are described. The structures of all compounds were confirmed by UV, IR, 1H-NMR, mass spectral data, and microanalyses. In the pharmacological studies, antidepressant an

Synthesis of some 1-[(N,N-disubstituted thiocarbamoylthio)acetyl]-3-(2- thienyl)-5-aryl-2-pyrazoline derivatives and investigation of their antibacterial and antifungal activities

Fourteen new 1-[(N,N-disubstituted thiocarbamoylthio)acetyl]-3-(2-thienyl)- 5-aryl-2-pyrazoline derivatives (7a-n) were synthesised by reacting 1-(chloroacetyl)-3-(2-thienyl)-5-aryl-2-pyrazolines (5a-g) and appropriate sodium salts of N,N-disubstituted dithiocarbamoic acids (6a, b). The structures of the synthesised compounds were confirmed by elemental analyses, UV, IR, 1H-NMR and FAB+-MS spectral data. Their antibacterial activities against Proteus vulgaris (NRRL B-123), Escherichia coli (NRRL B-3704), Aeromonas hydrophila (Ankara University, Faculty of Veterinary Sciences), Salmonella typhimurium (NRRL B-4420), Streptococcus feacalis (NRRL B-14617), Micrococcus luteus (NRLL B-4375) were investigated and in this investigation, a significant level of activity was illustrated. Antifungal activities of the compounds against Candida albicans and Candida globrata (isolates obtained from Osmangazi Uni. Fac. of Medicine) were found to be inactive. Compounds 7c-n were also evaluated for antituberculosis activity against Mycobacterium tuberculosis H37Rv using the BACTEC 460 radiometric system and BACTEC 12B medium. The preliminary results indicated that all of the tested compounds were inactive against the test organism.