136801-41-7Relevant academic research and scientific papers
Silver(II) oxide-mediated synthesis of 2,4-diarylquinazolines
Cheung, Wing,Patch, Raymond J.,Player, Mark R.
supporting information, p. 2368 - 2371 (2018/05/25)
A single-pot procedure for the synthesis of 2,4-diarylquinazolines is described which involves a silver oxide-mediated C–H activation/C–N bond formation process. The generality of this method with respect to substituent effects is presented along with studies leading to process optimization. Mechanistic investigations provide support for the involvement of radical intermediates in the reaction process.
Synthesis of Quinazolines from N,N′-Disubstituted Amidines via I2/KI-Mediated Oxidative C-C Bond Formation
Lv, Zhigang,Wang, Bingnan,Hu, Zhiyuan,Zhou, Yiming,Yu, Wenquan,Chang, Junbiao
, p. 9924 - 9930 (2016/11/02)
An I2/KI-promoted oxidative C-C bond formation reaction from C(sp3)-H and C(sp2)-H bonds has been used to construct quinazoline skeletons from N,N′-disubstituted amidines. The required substrates are readily prepared from the corresponding acyl chlorides, anilines, and alkyl/benzylamines by sequential amidation, chlorination, and amination reactions. Under the optimal oxidative cyclization conditions, all these amidines were conveniently transformed into the expected products in moderate to good yields. This practical and environmentally benign approach works well with crude amidine intermediates and can also be carried out on a gram scale.
A catalyst- and solvent-free selective approach to biologically important quinazolines and benzo[g]quinazoline
Kumar, Vipan,Mohan, Chander,Gupta, Manish,Mahajan, Mohinder P.
, p. 3533 - 3538 (2007/10/03)
A solvent-free and catalyst-free approach towards the selective synthesis of quinazolines and benzo[g] quinazolines has been developed using conventional microwave oven with excellent yields and reproducibilty.
Microwave Assisted Aza-Wittig Reactions of N-Imidoyliminophosphorane with Aldehydes: A Convenient and Selective Route to Quinazolines
Kumar, Vipan,Sharma, Ashwini,Mahajan, Mohinder P.
, p. 49 - 53 (2007/10/03)
A novel synthetic strategy for the selective synthesis of biologically important quinazolines with shorter reaction times, better yields, lower energy inputs and hassle free work up using a domestic microwave oven is reported.
A convenient synthesis of Quinazoline ring by tandem aza-Wittig reaction/electrocyclic ring closure
Rossi,Calabrese,Farma
, p. 5819 - 5834 (2007/10/02)
3,4-D-Dihydroquinazolines and Quinazolines were prepared starting from N'-aryl-N-(triphenylphosphoranilidene)-carboximidamides and aliphatic or aromatic aldehydes. The mechanism of the reaction is discussed.
