136801-58-6

Basic information

• Product Name: 5-fluoro-2,4-diphenylquinazoline
• Synonyms: 5-fluoro-2,4-diphenylquinazoline
• CAS NO: 136801-58-6
• Molecular Weight: 300.335
• Mol File: 136801-58-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 5-fluoro-2,4-diphenylquinazoline(CAS DataBase Reference)
• NIST Chemistry Reference: 5-fluoro-2,4-diphenylquinazoline(136801-58-6)
• EPA Substance Registry System: 5-fluoro-2,4-diphenylquinazoline(136801-58-6)

Safety Data

• Hazardous Substances Data: 136801-58-6(Hazardous Substances Data)

Upstream product

• 100-58-3 phenylmagnesium bromide 
• 3958-47-2 triphenylindium 
• 98-80-6 phenylboronic acid 
• 1098336-86-7 5-fluor-2-phenylquinazolin-4(3Η)-one 

Relevant articles and documents

Nickel-catalyzed Kumada Cross-coupling Reaction for the Synthesis of 2,4-Diarylquinazolines

A series of 2,4-diarylquinazolines have been successfully synthesized via the Ni-catalyzed cross-coupling reaction of quinazoline-4-tosylates and aryl Grignard reagents, which provided alternative straightforward approaches for the introduction of aryl groups to quinazolines at C-4 position.

Synthesis of 4-arylquinazolines by arylation of quinazolin-4-ones under mild conditions

An efficient route to 4-arylquinazolines via arylation of quinazolin-4-ones under mild condition is described. The reaction is carried out by the palladium-catalyzed coupling of quinazolin-4-ones with arylboronic acids in the presence of TsCl leading to 4-arylquinazolines in good to excellent yields. Georg Thieme Verlag Stuttgart New York.