1098336-86-7

Basic information

• Product Name: 5-fluor-2-phenylquinazolin-4(3Η)-one
• Synonyms: 5-fluor-2-phenylquinazolin-4(3Η)-one
• CAS NO: 1098336-86-7
• Molecular Weight: 240.237
• Mol File: 1098336-86-7.mol
• Article Data: 19

Chemical Properties

• CAS DataBase Reference: 5-fluor-2-phenylquinazolin-4(3Η)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 5-fluor-2-phenylquinazolin-4(3Η)-one(1098336-86-7)
• EPA Substance Registry System: 5-fluor-2-phenylquinazolin-4(3Η)-one(1098336-86-7)

Safety Data

• Hazardous Substances Data: 1098336-86-7(Hazardous Substances Data)

Upstream product

• 100-53-8 phenylmethanethiol 
• 115643-59-9 2-amino-6-fluorobenzamide 
• 591-50-4 iodobenzene 
• 144-62-7 oxalic acid 
• 77326-36-4 2-amino-6-fluorobenzonitrile 
• 100-51-6 benzyl alcohol 
• 393-52-2 2-Fluorobenzoyl chloride 
• 443647-45-8 2- fluoro-N-(quinolin-8-yl)benzamide 
• 1670-14-0 benzamidine monohydrochloride 
• 100-52-7 benzaldehyde 
• 1571119-70-4 2-phenyl-5-fluoro-2,3-dihydroquinazolin-4(1H)-one 
• 1885-29-6 anthranilic acid nitrile 
• 2252-37-1 2-bromo-6-fluorobenzoic acid 
• 108-86-1 bromobenzene 

Downstream Products

• 136801-58-6 5-fluoro-2,4-diphenylquinazoline 
• 1394844-67-7 5-fluoro-4-hydrazino-2-phenylquinazoline 
• 1394844-65-5 4 chloro-5-fluoro-2-phenylquinazoline 
• 1394844-78-0 3,5-dibromo-2-[(5-fluoro-2-phenylquinazolin-4-ylidene)hydrazonomethyl]phenyloxidozinc(II) acetate 
• 1394844-77-9 2-[(5-fluoro-2-phenylquinazolin-4-ylidene)hydrazonomethyl]-4-hydroxyphenyloxidozinc(II) acetate 
• 1394844-76-8 2-[(5-fluoro-2-phenylquinazolin-4-ylidene)hydrazonomethyl]phenyloxidozinc(II) acetate 
• 1394844-71-3 N (3,5-dibromosalicylidene)-N'-(5-fluoro-2-phenylquinazolin-4-yl)hydrazine 
• 1394844-70-2 N-(5-fluoro-2-phenylquinazolin-4-yl)-N'(4 hydroxysalicylidene)hydrazine 
• 1394844-69-9 N-(5-fluoro-2-phenylquinazolin-4-yl)-N'-salicylidenehydrazine 

Relevant articles and documents

Pd-catalyzed benzylic C-H amidation with benzyl alcohols in water: A strategy to construct quinazolinones

A novel method for the synthesis of 4-phenylquinazolinones via a palladium-catalyzed domino reaction of o-aminobenzamides with benzyl alcohols is developed. This protocol involves N-benzylation, benzylic C-H amidation, and dehydrogenation in water, which may play an important role in the smooth generation of the (η3-benzyl)palladium species by activation of the hydroxyl group of the benzyl alcohol.

Linear-Organic-Polymer-Supported Iridium Complex as a Recyclable Auto-Tandem Catalyst for the Synthesis of Quinazolinones via Selective Hydration/Acceptorless Dehydrogenative Coupling from o-Aminobenzonitriles

A linear-organic-polymer-supported iridium complex Cp*Ir@P4VP, which is designed and synthesized by the coordinative immobilization of [Cp*IrCl2]2 on poly(4-vinylpyridine), was proven to be an efficient heterogeneous autotandem catalyst for synthesizing quinazolinones via selective hydration/acceptorless dehydrogenative coupling from o-aminobenzonitriles. Furthermore, the synthesized catalyst was recycled five times without an obvious decrease in the catalytic activity.

An efficient transition-metal-free route to quinazolin-4(3H)-onesvia2-aminobenzamides and thiols

An efficient approach to quinazolin-4(3H)-ones was developed by a one-pot intermolecular annulation reaction ofo-amino benzamides and thiols. This method has the features of good functional group tolerance, being transition metal and external oxidant free, and easy operation. Varieties of 2-aryl (heteroaryl) quinazolin-4(3H)-one, 2-phenyl-pyrido[2,3-d]pyrimidin-4(3H)-one and 3-phenyl-2H-1,2,4-benzo thiadiazine-1,1-dioxide derivatives were obtained with a yield of up to 98%. The control experiment revealed that the thiol substrate could promote the dehydroaromatization step.