1098336-86-7

Upstream product

• 100-51-6 benzyl alcohol 
• 115643-59-9 2-amino-6-fluorobenzamide 
• 108-86-1 bromobenzene 
• 201230-82-2 carbon monoxide 
• 77326-36-4 2-amino-6-fluorobenzonitrile 
• 1885-29-6 anthranilic acid nitrile 
• 100-52-7 benzaldehyde 
• 100-53-8 phenylmethanethiol 
• 591-50-4 iodobenzene 
• 144-62-7 oxalic acid 
• 393-52-2 2-Fluorobenzoyl chloride 
• 443647-45-8 2- fluoro-N-(quinolin-8-yl)benzamide 
• 1670-14-0 benzamidine monohydrochloride 
• 1571119-70-4 2-phenyl-5-fluoro-2,3-dihydroquinazolin-4(1H)-one 

Downstream Products

• 136801-58-6 5-fluoro-2,4-diphenylquinazoline 
• 1394844-67-7 5-fluoro-4-hydrazino-2-phenylquinazoline 
• 1394844-65-5 4 chloro-5-fluoro-2-phenylquinazoline 
• 1394844-78-0 3,5-dibromo-2-[(5-fluoro-2-phenylquinazolin-4-ylidene)hydrazonomethyl]phenyloxidozinc(II) acetate 
• 1394844-77-9 2-[(5-fluoro-2-phenylquinazolin-4-ylidene)hydrazonomethyl]-4-hydroxyphenyloxidozinc(II) acetate 
• 1394844-76-8 2-[(5-fluoro-2-phenylquinazolin-4-ylidene)hydrazonomethyl]phenyloxidozinc(II) acetate 
• 1394844-71-3 N (3,5-dibromosalicylidene)-N'-(5-fluoro-2-phenylquinazolin-4-yl)hydrazine 
• 1394844-70-2 N-(5-fluoro-2-phenylquinazolin-4-yl)-N'(4 hydroxysalicylidene)hydrazine 
• 1394844-69-9 N-(5-fluoro-2-phenylquinazolin-4-yl)-N'-salicylidenehydrazine 

Relevant academic research and scientific papers

Pd-catalyzed benzylic C-H amidation with benzyl alcohols in water: A strategy to construct quinazolinones

A novel method for the synthesis of 4-phenylquinazolinones via a palladium-catalyzed domino reaction of o-aminobenzamides with benzyl alcohols is developed. This protocol involves N-benzylation, benzylic C-H amidation, and dehydrogenation in water, which may play an important role in the smooth generation of the (η3-benzyl)palladium species by activation of the hydroxyl group of the benzyl alcohol.

Access to 2-Arylquinazolin-4(3H)-ones through Intramolecular Oxidative C(sp3)?H/N?H Cross-Coupling Mediated by I2/DMSO

A novel approach for the synthesis of 2-arylquinazolin-4(3H)-ones was developed. A series of title compounds were obtained with good functional group tolerance and good yields by I2/DMSO-mediated intramolecular oxidative cross-coupling of 2-(benzylamino)benzamides to form C=N double bonds. This method was applicable for gram-scale synthesis. A proposed reaction pathway based on some control experiments was also provided.

Linear-Organic-Polymer-Supported Iridium Complex as a Recyclable Auto-Tandem Catalyst for the Synthesis of Quinazolinones via Selective Hydration/Acceptorless Dehydrogenative Coupling from o-Aminobenzonitriles

A linear-organic-polymer-supported iridium complex Cp*Ir@P4VP, which is designed and synthesized by the coordinative immobilization of [Cp*IrCl2]2 on poly(4-vinylpyridine), was proven to be an efficient heterogeneous autotandem catalyst for synthesizing quinazolinones via selective hydration/acceptorless dehydrogenative coupling from o-aminobenzonitriles. Furthermore, the synthesized catalyst was recycled five times without an obvious decrease in the catalytic activity.

Method for preparing 2 -phenyl quinazolinone compound

The invention relates to a preparation method of 2 -phenyl quinazolinone compounds, in particular to II. To the method, 2 - (benzylamino) benzamide compound (I) is used as a raw material for reaction of the experiment model, a simple substance iodine cata

An efficient transition-metal-free route to quinazolin-4(3H)-onesvia2-aminobenzamides and thiols

An efficient approach to quinazolin-4(3H)-ones was developed by a one-pot intermolecular annulation reaction ofo-amino benzamides and thiols. This method has the features of good functional group tolerance, being transition metal and external oxidant free, and easy operation. Varieties of 2-aryl (heteroaryl) quinazolin-4(3H)-one, 2-phenyl-pyrido[2,3-d]pyrimidin-4(3H)-one and 3-phenyl-2H-1,2,4-benzo thiadiazine-1,1-dioxide derivatives were obtained with a yield of up to 98%. The control experiment revealed that the thiol substrate could promote the dehydroaromatization step.

Ruthenium(II)-catalyzed C?C/C?N coupling of 2-arylquinazolinones with vinylene carbonate: Access to fused quinazolinones

In this work, ruthenium(II)-catalyzed C?C/C?N annulation of 2-arylquinazolinones with vinylene carbonate is reported to synthesize fused quinazolinones. This catalytic system tolerates a wide range of substrates with excellent functional-group compatibility. In this transformation, the vinylene carbonate acts as an ethynol surrogate without any external oxidant involved. Furthermore, preliminary mechanistic studies were conducted, and a plausible catalytic cycle was also proposed.

Polystyrene-Supported Palladium (Pd?PS)-Catalyzed Carbonylative Annulation of Aryl Iodides Using Oxalic Acid as a Sustainable CO Source for the Synthesis of 2-Aryl Quinazolinones

An efficient and convenient strategy for the synthesis of diversely substituted quinazolinones from o-carbamoyl/cyano aniline and aryl iodides using oxalic acid as a CO source under polystyrene supported palladium (Pd?PS) nanoparticles (NPs) catalyzed con

Method for synthesizing quinazolinone derivative

The invention discloses a method for synthesizing a quinazolinone derivative. According to the method for synthesizing the quinazolinone derivative,anthranilonitrile compounds and primary alcohols areused as raw materials, 2,2,6,6-tetramethylpiperidine ox

Copper-mediated synthesis of quinazolin-4(3: H)-ones from N-(quinolin-8-yl)benzamide and amidine hydrochlorides

An efficient copper-mediated tandem C(sp2)-H amination to provide quinazolinones from N-(quinolin-8-yl)benzamide and amidine hydrochlorides has been developed. It can afford rather complex products in a single step synthesis from easily availab

Chemoselective Trifluoroethylation Reactions of Quinazolinones and Identification of Photostability

Herein, we report chemoselective trifluoroethylation routes of unmasked 2-arylquinazolin-4(3H)-ones using mesityl(2,2,2-trifluoroethyl)iodonium triflate at room temperature. Homologous C-, O-, and N-functionalized subclasses are accessed in a straightforward manner with a wide substrate scope. These chemoselective branching events are driven by Pd-catalyzed ortho-selective C-H activation at the pendant aryl ring and base-promoted reactivity modulation of the amide group, leveraging the intrinsic directing capability and competing pronucleophilicity of the quinazolin-4(3H)-one framework. Furthermore, outstanding photostability of the quinazolin-4(3H)-one family associated with nonradiative decay is presented.