136818-50-3

Basic information

• Product Name: 1H-PYRROLO[2,3-B]PYRIDINE-2-CARBOXYLIC ACID
• Synonyms: 1H-PYRROLO[2,3-B]PYRIDINE-2-CARBOXYLIC ACID;1H-Pyrrolo[2,3-b]pyridine-2-carboxylicacid(9CI);7-Azaindole-2-carboxylic acid;7-Azaindole-2-carboxylic ...;1H-Pyrrolo[2,3-b]pyridine-2-carboxylic acid, 2-Carboxy-1H-pyrrolo[2,3-b]pyridine;1H-Pyrrolo[2,3-b]pyridin-2-carboxylic acid;1H-pyrrolo[2,3-b]pyridine-2-carbo×ylic acid;1H-Pyrrolo[2,3-b]pyridine-2-carboxylic Acid, 97+%
• CAS NO: 136818-50-3
• Molecular Formula: C₈H₆N₂O₂
• Molecular Weight: 162.15
• Product Categories: GLYCINESCAFFOLD;Heterocycle-Pyridine series
• Mol File: 136818-50-3.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 446.822 °C at 760 mmHg
• Flash Point: 224.03 °C
• Appearance: /
• Density: 1.507 g/cm³
• Vapor Pressure: 9.1E-09mmHg at 25°C
• Refractive Index: 1.743
• Storage Temp.: 2-8°C
• PKA: 0.04±0.20(Predicted)
• CAS DataBase Reference: 1H-PYRROLO[2,3-B]PYRIDINE-2-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-PYRROLO[2,3-B]PYRIDINE-2-CARBOXYLIC ACID(136818-50-3)
• EPA Substance Registry System: 1H-PYRROLO[2,3-B]PYRIDINE-2-CARBOXYLIC ACID(136818-50-3)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Hazardous Substances Data: 136818-50-3(Hazardous Substances Data)

Usage

General Description

1H-Pyrrolo[2,3-b]pyridine-2-carboxylic acid, also known as 2-Carboxy-1H-pyrrolo[2,3-b]pyridine, is a chemical compound with the molecular formula C9H6N2O2. It is a pyrrolopyridine derivative that is commonly used as a building block in the synthesis of pharmaceuticals and other organic compounds. 1H-Pyrrolo[2,3-b]pyridine-2-carboxylic acid has been studied for its potential anti-cancer and anti-inflammatory properties. It has also been investigated as a potential inhibitor of certain enzymes and pathways involved in disease progression. The chemical structure of 1H-Pyrrolo[2,3-b]pyridine-2-carboxylic acid makes it a versatile and valuable component in the development of new drugs and therapies.

InChI:InChI=1/C8H6N2O2/c11-8(12)6-4-5-2-1-3-9-7(5)10-6/h1-4H,(H,9,10)(H,11,12)

Upstream product

• 271-63-6 7-Azaindole 
• 124-38-9 carbon dioxide 
• 189089-90-5 1-(phenyl-sulfonyl)-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid 
• 577711-88-7 1-(tert-butyl) 2-ethyl 1H-pyrrolo[2,3-b]pyridine-1,2-dicarboxylate 
• 221675-35-0 1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid ethyl ester 
• 128071-75-0 2-bromopyridine-3-carboxaldehyde 
• 1603-40-3 3-methylpyridin-2-ylamine 
• 13534-99-1 2-Amino-3-bromopyridine 
• 127-17-3 2-oxo-propionic acid 
• 594-19-4 tert.-butyl lithium 

Downstream Products

• 1204475-66-0 3-bromo-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid 
• 1204475-64-8 3-chloro-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid 
• 1352805-44-7 1-(3-fluorophenyl)-N-methoxy-N-methyl-1H-pyrrolo[2,3-b]pyridine-2-carboxamide 
• 1352805-45-8 1-[1-(3-fluorophenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]ethanone 
• 1352805-46-9 1-[1-(3-fluorophenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]ethanamine 
• 1352805-47-0 tert-butyl {1-[1-(3-fluorophenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]ethyl}carbamate 
• 1352805-48-1 tert-butyl {1-[3-chloro-1-(3-fluorophenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]ethyl}carbamate 
• 1352805-49-2 1-[3-chloro-1-(3-fluorophenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]ethanamine 
• 1352805-60-7 tert-butyl {1-[3-fluoro-1-(3-fluorophenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]ethyl}carbamate 
• 1352805-61-8 1-[3-fluoro-1-(3-fluorophenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]ethanamine 
• 1352805-43-6 N-methoxy-N-methyl-1H-pyrrolo[2,3-b]pyridine-2-carboxamide 
• 271-63-6 7-Azaindole 
• 394223-03-1 1H-pyrrolo[2,3-b]pyridine-2-carbaldehyde 

Relevant articles and documents

HETEROCYCLIC COMPOUNDS AS PAD INHIBITORS

Heterocyclic compounds of Formula (I), (II), and (III) are described herein along with their polymorphs, stereoisomers, prodrugs, solvates, co-crystals, intermediates, pharmaceutically acceptable salts, and metabolites thereof. The compounds described herein, their polymorphs, stereoisomers, prodrugs, solvates, co-crystals, intermediates, pharmaceutically acceptable salts, and metabolites thereof are PAD4 inhibitors and may be useful in the treatment of various disorders, for example rheumatoid arthritis, vasculitis, systemic lupus erythematosis, cutaneous lupus erythematosis, ulcerative colitis, cancer, cystic fibrosis, asthma, multiple sclerosis and psoriasis.

ARYL-BIPYRIDINE AMINE DERIVATIVES AS PHOSPHATIDYLINOSITOL PHOSPHATE KINASE INHIBITORS

The invention relates to inhibitors of PI5P4K inhibitors useful in the treatment of cancers, neurodegenerative diseases, inflammatory disorders, and metabolic diseases, having the Formula (I): wherein A, X, Y, Z, Q, R1, R2, R3, R4, R5, and n are described herein.

Desulfonylation of indoles and 7-azaindoles using sodium tert-butoxide

A mild method for the desulfonylation of N-indoles and N-azaindoles is described. Deprotection is carried out under basic conditions, using sodium tert-butoxide in dioxane. Several functionalized indoles and 7-azaindoles were efficiently deprotected by this method, which is mild enough to be used to deprotect compounds including functions that are known to be sensitive to acidic or basic conditions.