13682-32-1

Usage

Uses

Used in Pharmaceutical Industry:
5-methyl-2-phenyl-1H-imidazole-4-methanol is used as an antifungal agent for treating a variety of fungal infections. It is effective against a wide range of fungi, including those responsible for athlete's foot, ringworm, and yeast infections, making it a popular choice for dermatological applications.
Used in Topical Formulations:
In the pharmaceutical industry, 5-methyl-2-phenyl-1H-imidazole-4-methanol is used as a key ingredient in topical formulations such as creams and powders. Its application in these forms allows for direct application to the affected area, providing a targeted approach to treating fungal infections of the skin.
Used in Oral and Intravaginal Formulations:
Beyond topical applications, 5-methyl-2-phenyl-1H-imidazole-4-methanol is also utilized in oral and intravaginal formulations. This versatility enables the medication to address fungal infections in different parts of the body, offering a comprehensive solution for various types of mycoses.
Used for Patient Safety and Tolerability:
5-methyl-2-phenyl-1H-imidazole-4-methanol is used in the development of antifungal medications due to its generally well-tolerated nature and low risk of side effects. This makes it an attractive option for patients who may be sensitive to other antifungal agents or who require long-term treatment.
Overall, 5-methyl-2-phenyl-1H-imidazole-4-methanol, or MICONAZOLE, is a valuable compound in the field of antifungal therapy, offering a range of applications across different formulations and treatment modalities to address the needs of patients with fungal infections.

InChI:InChI=1/C11H12N2O/c1-8-10(7-14)13-11(12-8)9-5-3-2-4-6-9/h2-6,14H,7H2,1H3,(H,12,13)

Upstream product

• 1670-14-0 benzamidine monohydrochloride 
• 431-03-8 dimethylglyoxal 
• 77335-93-4 ethyl 4-methyl-2-phenyl-1H-imidazole-5-carboxylate 
• 68282-50-8 5-Methyl-2-phenyl-4-imidazolecarboxaldehyde 

Downstream Products

• 68282-50-8 5-Methyl-2-phenyl-3H-imidazole-4-carbaldehyde 
• 195606-24-7 5-(2-Phenyl-5-methyl-3H-imidazol-4-ylmethylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione 
• 68283-02-3 8-methyl-6-phenyl-3H-imidazo[1,5-d][1,2,4]triazin-4-one 
• 69784-47-0 4-benzoyloxy-8-methyl-6-phenyl-imidazo[1,5-d][1,2,4]triazine 
• 69784-46-9 4-butyryloxy-8-methyl-6-phenyl-imidazo[1,5-d][1,2,4]triazine 
• 69784-45-8 4-acetoxy-8-methyl-6-phenyl-imidazo[1,5-d][1,2,4]triazine 

Relevant academic research and scientific papers

Synthesis and pharmacological evaluation of a novel series of 3-aryl-2-(2-substituted-4-methylthiazole-5-yl)thiazolidin-4-one as possible anti-inflammatory and antimicrobial agents

A new series of 3-aryl-2-(2-aryl/benzyl-4-methylthiazole-5-yl)thiazolidin- 4-one was synthesized by condensation of 2-aryl/benzyl-4-methylthiazole-5- carbaldehyde, aromatic amines and thioglycolic acid in toluene. All the synthesized compounds are characterized by IR, NMR and elemental or mass analysis. Sixteen out of the newly synthesized compounds were screened for in vivo anti-inflammatory activity using carrageenan-induced rat paw edema method. Some of the synthesized compounds exhibited good anti-inflammatory activity compared with indomethacin. The synthesized compounds were also evaluated for their in vitro antimicrobial activity. Some of the compounds showed mild antibacterial activity while most of the compounds showed good antifungal activity.

PATTERNED FINE PARTICLE FILM STRUCTURES

A patterned fine particle film structure includes a fine particle layer including fine particles arranged and bound to a surface of a substrate coated with a patterned film including a first film compound having a first functional group. The fine particles are coated with films including a first coupling agent having a first coupling reactive group that undergoes a coupling reaction with the first functional group to form a bond. The fine particle layer is bound by a bond formed through a coupling reaction. In an embodiment, fine particles coated with films of a film compound that reacts with the first coupling reactive group and the fine particles are alternately bound to the substrate.

New synthetic routes to pyrrolo-[1,2-a]- and -[1,2-c]-imidazol-5-ones by flash vacuum pyrolysis

1-Substituted and 1,3-disubstituted pyrrolo[1,2-c]imidazol-5-ones 25-27 have been made in fair to excellent yield by flash vacuum pyrolysis (FVP) of the Meldrum's acid precursors 11-13. FVP of the appropriate propenoate precursor 23, 22 and 18-20 gives pyrrolo[1,2-c]imidazol-5-one 2, pyrrolo[1,2-a]-imidazol-5-one 3 and their 6-methyl derivatives 28-30 respectively in 32-90% yield. The mechanism of the propenoate pyrolyses involves rate determining E to Z isomerisation of the alkene followed by elimination of an alcohol and electrocyclisation to the fused ring products.

IMIDAZO [1,5-d]-AS-TRIAZINE-4(3H)-ONES AND THIONES

There is provided substituted imidazo[1,5-d]-as-triazine-4(3H)-ones and substituted imidazo[1,5-d]-as-triazin-4(3H)-thiones useful as inhibitors of the enzyme cyclic-AMP phosphodiesterase and as broad spectrum herbicides

Substituted imidazo (1,5-D)-as-triazin-4-ols, and herbicidal use thereof

There are provided substituted imidazo[1,5-d]-as-triazin-4-ols, useful as herbicides for the pre- and postemergence control of undesired mono- and dicotyledonous plants.