68282-50-8

Basic information

• Product Name: 1H-Imidazole-4-carboxaldehyde, 5-methyl-2-phenyl-
• CAS NO: 68282-50-8
• Molecular Formula: C11H10N2O
• Molecular Weight: 186.213
• Mol File: 68282-50-8.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 1H-Imidazole-4-carboxaldehyde, 5-methyl-2-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Imidazole-4-carboxaldehyde, 5-methyl-2-phenyl-(68282-50-8)
• EPA Substance Registry System: 1H-Imidazole-4-carboxaldehyde, 5-methyl-2-phenyl-(68282-50-8)

Safety Data

• Hazardous Substances Data: 68282-50-8(Hazardous Substances Data)

Usage

Physical form

Yellow crystalline solid

Common uses

Organic synthesis, pharmaceutical research

Role

Key intermediate in the synthesis of various pharmaceutical compounds, building block for the preparation of heterocyclic compounds

Properties

Aromatic, imidazolic, unique structure valuable for drug development and chemical research

Potential applications

Medicine, biotechnology, pharmacological properties

Importance

Crucial in the development of novel drugs and pharmaceuticals

Upstream product

• 98-88-4 benzoyl chloride 
• 13682-32-1 4-Hydroxymethyl-5-methyl-2-phenyl-3H-imidazole 
• 77335-93-4 ethyl 4-methyl-2-phenyl-1H-imidazole-5-carboxylate 
• 1670-14-0 benzamidine monohydrochloride 
• 108512-07-8 N-(3-methyl-4-isoxazolyl)benzamide 

Downstream Products

• 195606-24-7 5-(2-Phenyl-5-methyl-3H-imidazol-4-ylmethylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione 
• 69784-47-0 4-benzoyloxy-8-methyl-6-phenyl-imidazo[1,5-d][1,2,4]triazine 
• 69784-46-9 4-butyryloxy-8-methyl-6-phenyl-imidazo[1,5-d][1,2,4]triazine 
• 69784-45-8 4-acetoxy-8-methyl-6-phenyl-imidazo[1,5-d][1,2,4]triazine 
• 69433-89-2 8-methyl-4-methylsulfanyl-6-phenyl-imidazo[1,5-d][1,2,4]triazine 
• 68282-92-8 8-methyl-6-phenyl-3H-imidazo[1,5-d][1,2,4]triazine-4-thione 
• 68283-02-3 8-methyl-6-phenyl-3H-imidazo[1,5-d][1,2,4]triazin-4-one 
• 68283-55-6 3,8-dimethyl-6-phenyl-3H-imidazo[1,5-d][1,2,4]triazine-4-thione 
• 68283-51-2 3,8-dimethyl-6-phenyl-3H-imidazo[1,5-d][1,2,4]triazin-4-one 
• 10045-55-3 2-phenyl-4-(1-hydroxyethyl)-5-methylimidazole 
• 119514-71-5 2-phenyl-4-(1-hydroxy-2-methylpropyl)-5-methyl-1H-imidazole 
• 13682-32-1 5-Methyl-2-phenyl-4-imidazolemethanol 
• 13682-20-7 4,5-dimethyl-2-phenyl-1H-imidazole 

Relevant articles and documents

Synthesis and pharmacological evaluation of a novel series of 3-aryl-2-(2-substituted-4-methylthiazole-5-yl)thiazolidin-4-one as possible anti-inflammatory and antimicrobial agents

A new series of 3-aryl-2-(2-aryl/benzyl-4-methylthiazole-5-yl)thiazolidin- 4-one was synthesized by condensation of 2-aryl/benzyl-4-methylthiazole-5- carbaldehyde, aromatic amines and thioglycolic acid in toluene. All the synthesized compounds are characterized by IR, NMR and elemental or mass analysis. Sixteen out of the newly synthesized compounds were screened for in vivo anti-inflammatory activity using carrageenan-induced rat paw edema method. Some of the synthesized compounds exhibited good anti-inflammatory activity compared with indomethacin. The synthesized compounds were also evaluated for their in vitro antimicrobial activity. Some of the compounds showed mild antibacterial activity while most of the compounds showed good antifungal activity.

Synthesis of 4(5)-Acyl-, 1-Substituted 5-Acyl, and 1-Substituted 4-Acyl-1H-imidazoles from 4-Aminoisoxazoles

4-Aminoisoxazoles can be acylated with a wide variety of activated carboxylic acids.Hydrogenation of the resulting amides gives α-(acylamino)enaminones, which cyclize to 4(5)-acylimidazoles upon treatment with base.This method allows for the synthesis of acylimidazoles with a wide range of substituents at C-2.Utilization of N-substituted 4-aminoisoxazoles in the same sequence of reactions yields 1-substituted 5-acylimidazoles, a substitution pattern not otherwise easily prepared.Treatment of α-(acylamino)enaminones, derived from N-unsubstituted isoxazoles, with primary amines leads to incorporation of the amine at the β-position with concomitant expulsion of ammonia.This sequence efficiently yields 1-substituted and 1,2-disubstituted 4-acylimidazoles but does not give satisfactory yields of 5-substituted 4-acylimidazoles due to steric inhibition of the amine exchange.

Method for the control of undesired plant species using imidazo-as-triazinones and triazine-thiones

This disclosure describes herbicidal methods for the pre- and postemergence control of undesired mono- and dicotyledonous plants using substituted imidazo[1,5-d]-as-triazin-4(3H)-ones and substituted imidazo[1,5-d]-as-triazine-4(3H)-thiones.