136834-39-4

Upstream product

• 961-07-9 2'-Deoxyguanosine 

Downstream Products

• 169766-20-5 Diphenyl-carbamic acid 9-{(2R,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-2-[3-(2,2,2-trifluoro-acetylamino)-propylamino]-9H-purin-6-yl ester 
• 169766-18-1 Diphenyl-carbamic acid 9-((2R,3aS,9aR)-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl)-2-[3-(2,2,2-trifluoro-acetylamino)-propylamino]-9H-purin-6-yl ester 
• 169766-19-2 Diphenyl-carbamic acid 9-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-2-[3-(2,2,2-trifluoro-acetylamino)-propylamino]-9H-purin-6-yl ester 
• 136834-44-1 N-{9-{(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-6-[2-(4-nitro-phenyl)-ethoxy]-9H-purin-2-yl}-N-(3-imidazol-1-yl-propyl)-isobutyramide 
• 136834-42-9 Isobutyric acid (2R,3S,5R)-5-{2-[(3-imidazol-1-yl-propyl)-isobutyryl-amino]-6-[2-(4-nitro-phenyl)-ethoxy]-purin-9-yl}-2-isobutyryloxymethyl-tetrahydro-furan-3-yl ester 
• 136834-43-0 N-{9-((2R,4S,5R)-4-Hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-6-[2-(4-nitro-phenyl)-ethoxy]-9H-purin-2-yl}-N-(3-imidazol-1-yl-propyl)-isobutyramide 

Relevant academic research and scientific papers

Formation of 2-chloroinosine from guanosine by treatment of HNO2 in the presence of NaCl

We investigated the reaction of Guo with nitrous acid in the presence of NaCl. When 1 mM Guo was incubated with 100 mM NaNO2 and 2 M NaCl in sodium acetate buffer at pH 3.2 and 37°C, 2-chloroinosine (2-Cl-Ino) was produced in addition to oxanosine (Oxo) and xanthosine (Xao). The yield of 2-Cl-Ino was 0.033 mM at an incubation time of 2 h. Under the same reaction conditions, GMP and dGuo gave rise to the corresponding 2-chloro derivatives with comparable yields. All the 2-chloro derivatives were fairly stable (t1/2>360 h) at physiological pH and temperature. To elucidate the reaction mechanism of the chlorination, the diazoate derivative of Guo, a reaction intermediate of the Guo-HNO2 system, was employed as a starting compound. When the diazoate was incubated with 2 M NaCl in a neutral solution, 2-Cl-Ino was produced in addition to Oxo and Xao. These results suggest that the 2-chloro derivatives can be produced from foodstuffs in the human stomach and may have potential importance as a carcinogen causing gastric cancer.