1368348-22-4

Usage

Uses

Used in Pharmaceutical Industry:
2-cyclopentyl-6-hydroxyisonicotinic acid is used as an anti-tubercular agent for its demonstrated effectiveness against drug-resistant strains of Mycobacterium tuberculosis. Its unique structure, featuring a cyclopentyl ring and a hydroxyl group, is thought to enhance its interaction with the bacterial target, leading to improved treatment outcomes for tuberculosis.
Used in Drug Development:
As a lead compound, 2-cyclopentyl-6-hydroxyisonicotinic acid is utilized in the research and development of novel anti-tuberculosis medications. Its potent activity and structural attributes make it a valuable candidate for further optimization and exploration in the quest to create more effective treatments for tuberculosis and potentially other infectious diseases.
Further research is necessary to fully understand the therapeutic potential of 2-cyclopentyl-6-hydroxyisonicotinic acid, including its safety profile, optimal dosage, and synergistic effects with existing treatments. This will be crucial in advancing its application in the pharmaceutical industry and drug development for combating tuberculosis and other related infectious diseases.

Upstream product

• 6004-60-0 1-cyclopentylethanone 
• 95-92-1 oxalic acid diethyl ester 
• 107-91-5 cyanoacetic acid amide 
• 1033443-97-8 ethyl 4-cyclopentyl-2,4-dioxobutanoate 
• 64-19-7 acetic acid 

Downstream Products

• 1122089-67-1 2-cyclopentyl-6-methoxypyridine-4-carboxylic acid 

Relevant academic research and scientific papers

Synthetic method of novel feed additive

The invention discloses a synthetic method of a novel feed additive and belongs to the technical field of synthesis of feed additives. The novel feed additive has the structure shown in the specification, wherein R1 is an oxygen atom or a nitrogen atom, R2 is cyclopentane, cyclobutane or cyclopropane, and R3 is methyl, ethyl or phenyl. The invention further discloses a preparation method of the novel feed additive. The novel feed additive is synthesized with the novel method, operation is simple and easy to perform in the reaction process, raw materials are low in price and easy to obtain, the reaction efficiency is relatively high, the repetition is relatively good, and the novel feed additive has a good growth promoting function on grow-finishing pigs.

Synthesizing method for novel S1P-1 receptor stimulant drug molecule with antitumor activity

The invention discloses a synthesizing method for a novel S1P-1 receptor stimulant drug molecule with antitumor activity, belonging to the technical field of medicine synthesis. The key point of the technical scheme of the invention is that the novel S1P-1 receptor stimulant drug molecule with antitumor activity has a structure as shown in the specification. The invention also discloses a preparation method for the novel S1P-1 receptor stimulant drug molecule with antitumor activity. According to the invention, a new method is used for synthesizing the novel S1P-1 receptor stimulant drug molecule with antitumor activity; reaction process and operation are simple and feasible; the raw materials are low in cost and are easily available; the reaction efficiency is relatively high and the repeatability is good; the antitumor bioactivity effect is obvious.

Preparation method of novel anti-ultraviolet plastic additive

The invention discloses a preparation method of a novel anti-ultraviolet plastic additive and belongs to the technical field of plastic additive synthesis. The novel anti-ultraviolet plastic additive has a structure described in the specification, wherein R1 is an oxygen atom or nitrogen atom; and R2 is cyclopentane, cyclobutane or cyclopropane; and R3 is methyl, ethyl or phenyl. The invention also discloses a preparation method of the novel anti-ultraviolet plastic additive. According to the invention, a new anti-ultraviolet plastic additive is synthesized by virtue of a new method, reaction process operation is simple and practicable, raw materials are cheap and available, reaction efficiency is relatively high and repeatability is relatively good, and the novel anti-ultraviolet plastic additive has a good anti-ultraviolet radiation ageing effect on plastic.

Practical Synthesis of a S1P Receptor 1 Agonist via a Guareschi-Thorpe Reaction

A practical synthesis of S1P receptor 1 agonist ACT-334441 (1) through late-stage convergent coupling of two key intermediates is described. The first intermediate is 2-cyclopentyl-6-methoxyisonicotinic acid whose skeleton was built from 1-cyclopentylethanone, ethyl oxalate, and cyanoacetate in a Guareschi-Thorpe reaction in 42% yield over five steps. The second, chiral intermediate, is a phenol ether derived from enantiomerically pure (R)-isopropylidene glycerol ((R)-solketal) and 3-ethyl-4-hydroxy-5-methylbenzonitrile in 71% yield in a one-pot reaction. The overall sequence entails 18 chemical steps with 10 isolated intermediates. All raw materials are cheap and readily available in bulk quantities, the reaction conditions match with standard pilot plant equipment, and the route reproducibly afforded 3-20 kg of 1 in excellent purity and yield for clinical studies.