136846-87-2Relevant academic research and scientific papers
Synthesis and Reactivity of 3-Oxazolines
Weber, Maya,Jakob, Juergen,Martens, Juergen
, p. 1 - 6 (2007/10/02)
3-Oxazolines 1 have been prepared from α-hydroxy aldehydes, ammonia, water and a second oxo compound (aldehyde or ketone) in a one-pot reaction.Carboxylic acid chlorides add to the azomethine bond of 1 to yield 3-acyl-4-chlorooxazolidines 2. 4-Hydroxy and 4-alkoxyoxazolidines 3 are obtained from 2 upon treatment with aqueons sodium hydroxide or alkanol/triethyl amine, respectively.Some oxazolidines 3 are formed with high diastereoselectivity. Key Words: Oxazole, 2,5-dihydro- / Oxazolidine / Acyliminium ion
