136848-23-2

Upstream product

• 55516-30-8 2,3,4-tri-O-methyl ether of methyl α-L-fucopyranoside 
• 136848-19-6 p-(2-methoxycarbonylethyl)phenyl 4-O-benzyl-2-O-methyl-3-O-(3-O-acetyl-2,4-di-O-benzyl-α-L-rhamnopyranosyl)-α-L-rhamnopyranoside 
• 136848-18-5 2-(methoxycarbonylethyl)phenyl 4-O-benzyl-2-O-methyl-α-L-rhamnopyranoside 
• 136848-21-0 1-O-acetyl-6-deoxy-2,3,4-tri-O-methyl-β-L-galactopyranose 
• 4613-15-4 benzyl 4-O-benzyl-α-L-rhamnopyranoside 
• 69558-14-1 benzyl 4-O-benzyl-2-O-methyl-α-L-rhamnopyranoside 
• 133841-75-5 2,3,4-tri-O-methyl-α-L-fucopyranosyl chloride 
• 136848-20-9 p-(2-methoxycarbonylethyl)phenyl 4-O-benzyl-2-O-methyl-3-O-(2,4-di-O-benzyl-α-L-rhamnopyranosyl)-α-L-rhamnopyranoside 

Relevant academic research and scientific papers

Synthesis of the trisaccharide-protein conjugate of the phenolic glycolipid of Mycobacterium tuberculosis for the serodiagnosis of tuberculosis.

The trisaccharide segment of the phenolic glycolipid (PGL) of Mycobacterium tuberculosis, 2-O-methyl-3-O-[3-O-(2,3,4-tri-O-methyl-alpha-L-fucopyranosyl)-alpha-L- rhamnopyranosyl]-alpha-L-rhamnopyranose, was synthesized in the form of the p-(2-methoxycarbonylethyl)phenyl glycoside by a stepwise condensation. 2,4-Di-O-benzyl-3-O-acetyl-alpha-L-rhamnopyranosyl chloride was coupled to p-(2-methoxycarbonylethyl)phenyl 4-O-benzyl-2-O-methyl-alpha-L-rhamnopyranoside in the presence of silver triflate, and 2,3,4-tri-O-methyl-alpha-L-rhamnopyranosyl chloride was then coupled to the deacetylated disaccharide by the same procedure. The trisaccharide was deblocked and coupled to BSA, giving the neoglycoconjugate TB-NT-P-BSA. TB-NT-P-BSA showed its possibility as a useful tool for the serodiagnosis of tuberculosis.