136880-99-4Relevant academic research and scientific papers
Diastereoselective synthesis of the C29-C41 fragment of karlotoxin 2
Reddy, D. Srinivas,Gaddam, Janardhan,Devunuri, Nagaraju,Mohapatra, Debendra K.
, p. 4299 - 4301 (2015)
A highly diastereoselective synthesis of the C29-C41 fragment of karlotoxin 2 (KmTx2) is described by employing regio-selective epoxide opening, our own developed domino isomerization followed by C-O and C-C bond formation reaction and chelation-controlled Grignard reaction as key steps. The synthesis involves installation of seven stereocenters present in the C29-C41 fragment of karlotoxin 2.
