136906-08-6

Usage

InChI:InChI=1/C19H26N2O/c1-3-9-21(10-4-2)16-7-5-14-6-8-18-19(17(14)11-16)15(13-22)12-20-18/h6,8,12-13,16,20H,3-5,7,9-11H2,1-2H3

Upstream product

• 68-12-2 N,N-dimethyl-formamide 
• 83343-44-6 6,7,8,9-tetrahydro-N,N-dipropyl-3H-benz[e]indol-8-amine 
• 149884-86-6 (R)-N,N-di-n-propyl-6,7,8,9-tetrahydro-3H-benzindol-8-ylamine 
• 2444-36-2 2'-chloro-benzeneacetic acid 
• 82302-27-0 8-chloro-3,4-dihydro-2(1H)-naphthalenone 
• 136906-01-9 7-amino-8-chloro-2-(N-n-propyl-N-propionylamino)tetralin 
• 136905-98-1 8-chloro-2-(N-n-propyl-N-propionyl-amino)-1,2,3,4-tetrahydronaphthalene 
• 149884-88-8 (S)-N,N-di-n-propyl-6,7,8,9-tetrahydro-3H-benzindol-8-ylamine 
• 136906-00-8 8-chloro-7-nitro-2-(n-propyl-N-propionylamino)-1,2,3,4-tetrahydronaphthalene 
• 51512-09-5 2-(2-chlorophenyl)acetyl chloride 
• 83343-37-7 7-amino-2-N,N-dipropylamino-1,2,3,4-tetrahydronaphthalene 
• 83343-42-4 6,7,8,9-tetrahydro-8-(dipropylamino)-3H-benzindole-1,2-dione 

Relevant academic research and scientific papers

Centrally acting 6,7,8,9-tetrahydro-3H-benz(E)indole heterocyclics

A compound of Formula I STR1 or pharmaceutically acceptable salts of Formula I, where R1 is H, C1 -C3 alkyl, --(CH2)n CONH2 where n is 2 to 6, (CH2)n -1-(4,4-dimethylpiperidine-2

Centrally acting 6,7,8,9-tetrahydro-3H-benz(e)indole heterocyclics

A compound of Formula I STR1 or pharmaceutically acceptable salts of Formula I, where R 1 is H, C 1 -C 3 alkyl, --(CH 2) n CONH 2 where n is 2 to 6, (CH2) n -1-(4,4-dimethylpiperidine-2,6-dione-yl), or cyclopropylmethyl;R 2 is hydrogen, C 1 -C 8 alkyl, C

Synthesis of (R)- and (S)-1-formyl-6,7,8,9-tetrahydro-N,N-(dipropyl)-3H- benz[e]indol-8-amines: Potent and orally active 5-HT(1A) receptor agonists

An efficient synthesis of the potent and orally active 5-HT(1A) agonists, (R)-(+)- and (S)-(-)-l-formyl-6,7,8,9-tetrahydro-N,N-dipropyl-3H- benz[e]indol-8-amines 1a and 1b, is described. This synthesis was accomplished in twelve steps from commercially av

(S)- and (R)-8-(di-n-propylamino)-6,7,8,9-tetrahydro-3H-benz[e]indole-1- carbaldehyde: A new class of orally active 5-HT(1A)-receptor agonists

The enantiomers of 6,7,8,9-tetrahydro-N,N-di-n-propyl-3H-benz[e]indol-8- amine (S-(-)-2b and R-(+)-2b) and their corresponding 1-formyl analogs (S-(- )-6 and R-(+)-6 were prepared and evaluated pharmacologically for serotonergic and dopaminergic activity. The introduction of a formyl group in the 1-position shifted the pharmacological profile of 2b from a mixed D2/5- HT(1A) agonists to a selective 5-HT(1A) agonist (6). The enantiomers of 6 were agonists with full intrinsic activity and had an affinity comparable to that of 8-hydroxy-2-(di-n-propylamino)tetrahydronaphthalene (8-OH-DPAT). In contrast to 8-OH-DPAT, the enantiomers of compound 6 were found to have good oral availability.