136906-33-7 Usage
Uses
Used in Pharmaceutical Industry:
CYCLOPROPYL 3,4-DICHLOROPHENYL KETONE is used as an intermediate in the synthesis of various pharmaceuticals. Its unique structure allows it to be a key component in the development of new drugs, enhancing the range of treatments available for different medical conditions.
Used in Agrochemicals:
CYCLOPROPYL 3,4-DICHLOROPHENYL KETONE is also utilized in the synthesis of agrochemicals, playing a crucial role in the development of new pesticides and other agricultural products. Its properties make it a valuable component in creating effective solutions for crop protection and management.
Used in Organic Synthesis:
CYCLOPROPYL 3,4-DICHLOROPHENYL KETONE is used as a building block in organic synthesis for creating new compounds. Its reactivity and structural features make it an important precursor in the development of a wide range of chemical products, from specialty chemicals to advanced materials.
Used in Chemical Research:
In the field of chemical research, CYCLOPROPYL 3,4-DICHLOROPHENYL KETONE serves as a valuable compound for studying reaction mechanisms and exploring new methods in synthetic chemistry. Its unique properties provide opportunities for scientists to investigate novel approaches and techniques in chemical synthesis.
Check Digit Verification of cas no
The CAS Registry Mumber 136906-33-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,6,9,0 and 6 respectively; the second part has 2 digits, 3 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 136906-33:
(8*1)+(7*3)+(6*6)+(5*9)+(4*0)+(3*6)+(2*3)+(1*3)=137
137 % 10 = 7
So 136906-33-7 is a valid CAS Registry Number.
InChI:InChI=1/C10H8Cl2O/c11-8-4-3-7(5-9(8)12)10(13)6-1-2-6/h3-6H,1-2H2
136906-33-7Relevant academic research and scientific papers
Synthesis and Pharmacology of (Pyridin-2-yl)methanol Derivatives as Novel and Selective Transient Receptor Potential Vanilloid 3 Antagonists
Gomtsyan, Arthur,Schmidt, Robert G.,Bayburt, Erol K.,Gfesser, Gregory A.,Voight, Eric A.,Daanen, Jerome F.,Schmidt, Diana L.,Cowart, Marlon D.,Liu, Huaqing,Altenbach, Robert J.,Kort, Michael E.,Clapham, Bruce,Cox, Phil B.,Shrestha, Anurupa,Henry, Rodger,Whittern, David N.,Reilly, Regina M.,Puttfarcken, Pamela S.,Brederson, Jill-Desiree,Song, Ping,Li, Bin,Huang, Susan M.,McDonald, Heath A.,Neelands, Torben R.,McGaraughty, Steve P.,Gauvin, Donna M.,Joshi, Shailen K.,Banfor, Patricia N.,Segreti, Jason A.,Shebley, Mohamad,Faltynek, Connie R.,Dart, Michael J.,Kym, Philip R.
, p. 4926 - 4947 (2016/06/13)
Transient receptor potential vanilloid 3 (TRPV3) is a Ca2+- and Na+-permeable channel with a unique expression pattern. TRPV3 is found in both neuronal and non-neuronal tissues, including dorsal root ganglia, spinal cord, and keratinocytes. Recent studies suggest that TRPV3 may play a role in inflammation, pain sensation, and skin disorders. TRPV3 studies have been challenging, in part due to a lack of research tools such as selective antagonists. Herein, we provide the first detailed report on the development of potent and selective TRPV3 antagonists featuring a pyridinyl methanol moiety. Systematic optimization of pharmacological, physicochemical, and ADME properties of original lead 5a resulted in identification of a novel and selective TRPV3 antagonist 74a, which demonstrated a favorable preclinical profile in two different models of neuropathic pain as well as in a reserpine model of central pain.
