200802-01-3

Usage

Uses

Used in Agricultural Industry:
Diclosulam is used as a herbicidal agent for controlling a wide range of broadleaf weeds in crops such as soybeans, wheat, and barley. It functions by inhibiting the acetolactate synthase (ALS) enzyme, which is crucial for the production of branched-chain amino acids in plants. This disruption in protein synthesis leads to the death of the targeted weeds, making Diclosulam highly effective in controlling herbicide-resistant weeds.
Furthermore, Diclosulam is valued for its low environmental impact, as it degrades quickly in the soil and has minimal leaching potential. However, it is essential to use this chemical with caution and adhere to safety guidelines to minimize potential risks to human health and the environment.

Upstream product

• 6638-79-5 N,O-dimethylhydroxylamine*hydrochloride 
• 3024-72-4 3,4-dichlorobenzoyl chloride 
• 1262210-37-6 3,4-dichlorophenyl 1,1,2,2,3,3,4,4,4-nonafluorobutane-1-sulfonate 
• 13939-06-5 molybdenum hexacarbonyl 
• 1117-97-1 N,0-dimethylhydroxylamine 

Downstream Products

• 122453-88-7 3',4'-dichloro-3-(1,3-dioxolan-2-yl)-propiophenone 
• 648869-68-5 (E)-1-(3,4-dichlorophenyl)-3-(methoxymethylamino)-4-[(tetrahydro-2H-pyran-2-yl)oxy]-2-buten-1-one 
• 937791-13-4 C₁₄H₁₅Cl₂NO₄ 
• 937791-15-6 C₁₄H₁₆Cl₃NO₂ 
• 937791-12-3 C₁₃H₁₃Cl₂NO₄ 
• 937791-14-5 C₁₇H₁₅Cl₂NO₂ 
• 937791-24-7 (Z)-2-Amino-4-(3,4-dichloro-phenyl)-4-oxo-but-2-enoic acid methyl ester 
• 147580-41-4 6-(3,4-Dichlorophenyl)-3,4-dihydro-1-methylpyrrolo[1,2-a]pyrazine 
• 147030-69-1 N-[2-[2-(3,4-dichlorophenyl)-pyrrol-1-yl]ethyl]acetamide 
• 648869-67-4 1-(3,4-dichlorophenyl)-4-[(tetrahydro-2H-pyran-2-yl)oxy]-2-butyn-1-one 
• 648869-69-6 (Z)-1-(3,4-dichlorophenyl)-3-hydroxy-4-[(tetrahydro-2H-pyran-2-yl)oxy]-2-buten-1-one 
• 828918-94-1 (E)-1-(3,4-dichlorophenyl)-3-(methoxymethylamino)-4-acetyl-2-buten-1-one 
• 876056-83-6 tert-butyl 4-(3,4-dichlorophenyl)-4-oxobut-2-ynoate 
• 50516-63-7 1-(3,4-dichlorophenyl)-3-(dimethylamino)-1-propanone 

Relevant academic research and scientific papers

Tuning the activity of known drugs via the introduction of halogen atoms, a case study of SERT ligands – Fluoxetine and fluvoxamine

The selective serotonin reuptake inhibitors (SSRIs), acting at the serotonin transporter (SERT), are one of the most widely prescribed antidepressant medications. All five approved SSRIs possess either fluorine or chlorine atoms, and there is a limited number of reports describing their analogs with heavier halogens, i.e., bromine and iodine. To elucidate the role of halogen atoms in the binding of SSRIs to SERT, we designed a series of 22 fluoxetine and fluvoxamine analogs substituted with fluorine, chlorine, bromine, and iodine atoms, differently arranged on the phenyl ring. The obtained biological activity data, supported by a thorough in silico binding mode analysis, allowed the identification of two partners for halogen bond interactions: the backbone carbonyl oxygen atoms of E493 and T497. Additionally, compounds with heavier halogen atoms were found to bind with the SERT via a distinctly different binding mode, a result not presented elsewhere. The subsequent analysis of the prepared XSAR sets showed that E493 and T497 participated in the largest number of formed halogen bonds. The XSAR library analysis led to the synthesis of two of the most active compounds (3,4-diCl-fluoxetine 42, SERT Ki = 5 nM and 3,4-diCl-fluvoxamine 46, SERT Ki = 9 nM, fluoxetine SERT Ki = 31 nM, fluvoxamine SERT Ki = 458 nM). We present an example of the successful use of a rational methodology to analyze binding and design more active compounds by halogen atom introduction. ‘XSAR library analysis’, a new tool in medicinal chemistry, was instrumental in identifying optimal halogen atom substitution.

Rhoda-Electrocatalyzed Bimetallic C?H Oxygenation by Weak O-Coordination

Rhodium-electrocatalyzed arene C?H oxygenation by weakly O-coordinating amides and ketones have been established by bimetallic electrocatalysis. Likewise, diverse dihydrooxazinones were selectively accessed by the judicious choice of current, enabling twofold C?H functionalization. Detailed mechanistic studies by experiment, mass spectroscopy and cyclovoltammetric analysis provided support for an unprecedented electrooxidation-induced C?H activation by a bimetallic rhodium catalysis manifold.

Mo(CO)6 as a Solid CO Source in the Synthesis of Aryl/Heteroaryl Weinreb Amides under Microwave-Enhanced Condition

The facile transformation of aryl/heteroaryl nonaflates into corresponding amides via Pd-catalyzed aminocarbonylation using Mo(CO)6 as a solid CO source under microwave-enhanced condition is reported. The method was found to be tolerant with respect to a

A facile one-pot synthesis of acyclic β-enamino ketones, an important class of versatile synthetic intermediates

A one-pot sequential process consisting of nucleophilic substitution of the lithiated acetylides with Weinreb amides followed by a Michael reaction of the extruded N-methoxy-N-methylamine after quenching with saturated NH4Cl, provided β-enamino ketones in high yield and in a single geometrical isomeric form. It has been demonstrated that this method is applicable to a wide variety of such amides and to different acetylides.

PYRAZOLE AMIDE DERIVATIVES, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF USE

Pyrazole amides are disclosed. The compounds are useful for treating type 2 diabetes and related conditions. Pharmaceutical compositions and methods of treatment are also included.

CCK-1 RECEPTOR MODULATORS

There are provided by the present invention certain pyrazole based CCK-1 receptor modulators which have the general formula: (I) wherein Ar is an aromatic or heteroaromatic group, X is a hydrocarbon linker, Y is a bond or hydrocarbon linker and R1, R2, R3, R4 and R5 are certain organic substituents, and methods of making the same.

CCK-1 RECEPTOR MODULATORS

There are provided by the present invention certain pyrazole based CCK-1 receptor modulators.

[Bis(2-methoxyethyl)amino]sulfur Trifluoride, the Deoxo-Fluor Reagent: Application toward One-Flask Transformations of Carboxylic Acids to Amides

The use of the Deoxo-Fluor reagent is a versatile method for acyl fluoride generation and subsequent one-flask amide coupling. It provides mild conditions and facile purification of the desired products in good to excellent yields. We have explored the utility of this reagent for the one-flask conversion of acids to amides and Weinreb amides and as a peptide-coupling reagent.