136916-19-3

Basic information

• Product Name: 2-Fluoro-6-nitrophenylacetic acid
• Synonyms: 2-Fluoro-6-nitrophenylacetic acid;2-(2-Fluoro-6-nitrophenyl)acetic acid;BENZENEACETIC ACID, 2-FLUORO-6-NITRO-
• CAS NO: 136916-19-3
• Molecular Formula: C₈H₆FNO₄
• Molecular Weight: 199.1359432
• Mol File: 136916-19-3.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 344.4±27.0 °C(Predicted)
• Appearance: /
• Density: 1.498±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 3.66±0.10(Predicted)
• CAS DataBase Reference: 2-Fluoro-6-nitrophenylacetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Fluoro-6-nitrophenylacetic acid(136916-19-3)
• EPA Substance Registry System: 2-Fluoro-6-nitrophenylacetic acid(136916-19-3)

Safety Data

• Hazardous Substances Data: 136916-19-3(Hazardous Substances Data)

Usage

General Description

2-Fluoro-6-nitrophenylacetic acid is a chemical compound with the molecular formula C8H6FNO4. It is a derivative of phenylacetic acid with a fluorine atom at the 2-position and a nitro group at the 6-position of the phenyl ring. 2-Fluoro-6-nitrophenylacetic acid is a known organic building block used in the synthesis of pharmaceuticals and other organic compounds. It is also used as a reagent in organic chemistry reactions and as a research tool in medicinal chemistry. The chemical properties of 2-Fluoro-6-nitrophenylacetic acid make it an important molecule for drug discovery and development.

Upstream product

• 872141-24-7 2-(3-fluoro-2-nitrophenyl)malonic acid dimethyl ester 
• 6921-22-8 1,2-difluoro-3-nitrobenzene 
• 866209-62-3 2-(2-fluoro-6-nitrophenyl)malonic acid dimethyl ester 

Downstream Products

• 71294-03-6 7-fluoro-1,3-dihydro-indol-2-one 
• 1357192-61-0 methyl 1-(2-fluoro-6-nitrophenyl)cyclobutanecarboxylate 
• 1357192-60-9 4′-fluoro-5′-[5-methoxy-4-oxo-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-1(4H)-yl]-1'-methylspiro[cyclobutane-1,3'-indol]-2'(1'H)-one 
• 887587-80-6 C₈H₈FNO₂ 
• 138343-94-9 4-fluoro-1,3-dihydro-2H-indol-2-one 

Relevant articles and documents

Design and synthesis of a novel 2-oxindole scaffold as a highly potent and brain-penetrant phosphodiesterase 10A inhibitor

Highly potent and brain-penetrant phosphodiesterase 10A (PDE10A) inhibitors based on the 2-oxindole scaffold were designed and synthesized. (2-Oxo-1,3-oxazolidin-3-yl)phenyl derivative 1 showed the high P-glycoprotein (P-gp) efflux (efflux ratio (ER) = 6.

Design, synthesis, and SAR of new pyrrole-oxindole progesterone receptor modulators leading to 5-(7-fluoro-3,3-dimethyl-2-oxo-2,3-dihydro-1H-indol-5-yl)- 1-methyl-1H-pyrrole-2-carbonitrile (WAY-255348)

We have continued to explore the 3,3-dialkyl-5-aryloxindole series of progesterone receptor (PR) modulators looking for new agents to be used in female healthcare: contraception, fibroids, endometriosis, and certain breast cancers. Previously we reported

Substituted propylamine derivatives and methods of their use

The present invention is directed to substituted propylamine derivatives of formula I: or a pharmaceutically acceptable salt thereof, compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions ameliorated by monoamine reuptake including, inter alia, vasomotor symptoms (VMS), sexual dysfunction, gastrointestinal and genitourinary disorders, chronic fatigue syndrome, fibromylagia syndrome, nervous system disorders, and combinations thereof, particularly those conditions selected from the group consisting of major depressive disorder, vasomotor symptoms, stress and urge urinary incontinence, fibromyalgia, pain, diabetic neuropathy, and combinations thereof.