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1369257-58-8

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1369257-58-8 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1369257-58-8 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,6,9,2,5 and 7 respectively; the second part has 2 digits, 5 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 1369257-58:
(9*1)+(8*3)+(7*6)+(6*9)+(5*2)+(4*5)+(3*7)+(2*5)+(1*8)=198
198 % 10 = 8
So 1369257-58-8 is a valid CAS Registry Number.

1369257-58-8Relevant articles and documents

Tricyclic dihydroimidazopyrimidinone derivative, and preparation method, pharmaceutical composition and application thereof

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Paragraph 0425-0428; 0429; 0432, (2021/05/12)

The invention provides a compound as shown in a general formula (I), cis-trans isomers, enantiomers, diastereoisomers, racemes, solvates, hydrates or pharmaceutically acceptable salts or prodrugs of the compound, a preparation method of the compound, a pharmaceutical composition containing the compound and an application of the compound as aLp-PLA2 inhibitor, wherein R1, R2, Rx, Ra, Q, U, X, Y, m, n and A are defined in the specification.

Discovery of a Novel Series of Imidazo[1,2-a]pyrimidine Derivatives as Potent and Orally Bioavailable Lipoprotein-Associated Phospholipase A2 Inhibitors

Chen, Xinde,Xu, Wenwei,Wang, Kai,Mo, Mingguang,Zhang, Wei,Du, Lili,Yuan, Xiaojing,Xu, Yechun,Wang, Yiping,Shen, Jianhua

, p. 8529 - 8541 (2015/11/24)

Inhibition of lipoprotein-associated phospholipase A2 (Lp-PLA2) has been suggested to be a promising therapeutic strategy for several inflammation-associated diseases, including atherosclerosis, Alzheimer's disease, and diabetic macu

BICYCLIC PYRIMIDONE COMPOUNDS

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Paragraph 0180; 0217, (2014/07/08)

The present invention relates to novel bicyclic pyrimidone compounds that inhibit Lp-PLA2 activity, processes for their preparation, to compositions containing them and to their use in the treatment of diseases associated with the activity of Lp-PLA2, for example atherosclerosis, Alzheimer's disease.

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