1369323-99-8

Basic information

• Product Name: 5'-O-(4,4'-dimethoxytrityl)-3'-O-[(N,N-diisopropylamino)-(2-cyanoethyl)]phosphinyl-2'-O-[2-(methylsulfinyl)ethanimine-N-oxymethyl]uridine
• Synonyms: 5'-O-(4,4'-dimethoxytrityl)-3'-O-[(N,N-diisopropylamino)-(2-cyanoethyl)]phosphinyl-2'-O-[2-(methylsulfinyl)ethanimine-N-oxymethyl]uridine
• CAS NO: 1369323-99-8
• Molecular Weight: 879.968
• Mol File: 1369323-99-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 5'-O-(4,4'-dimethoxytrityl)-3'-O-[(N,N-diisopropylamino)-(2-cyanoethyl)]phosphinyl-2'-O-[2-(methylsulfinyl)ethanimine-N-oxymethyl]uridine(CAS DataBase Reference)
• NIST Chemistry Reference: 5'-O-(4,4'-dimethoxytrityl)-3'-O-[(N,N-diisopropylamino)-(2-cyanoethyl)]phosphinyl-2'-O-[2-(methylsulfinyl)ethanimine-N-oxymethyl]uridine(1369323-99-8)
• EPA Substance Registry System: 5'-O-(4,4'-dimethoxytrityl)-3'-O-[(N,N-diisopropylamino)-(2-cyanoethyl)]phosphinyl-2'-O-[2-(methylsulfinyl)ethanimine-N-oxymethyl]uridine(1369323-99-8)

Safety Data

• Hazardous Substances Data: 1369323-99-8(Hazardous Substances Data)

Upstream product

• 1369323-96-5 5'-O-(4,4'-dimethoxytrityl)-2'-O-[2-(methylsulfinyl)ethanimine-N-oxymethyl]uridine 
• 124482-92-4 2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine 
• 1369323-95-4 2'-O-[2-(methylthio)ethanimine-N-oxymethyl]uridine 
• 1369323-42-1 2'-O-(aminooxymethyl)uridine 

Relevant articles and documents

2'-O-AMINOOXYMETHYL NUCLEOSIDE DERIVATIVES FOR USE IN THE SYNTHESIS AND MODIFICATION OF NUCLEOSIDES, NUCLEOTIDES AND OLIGONUCLEOTIDES

Disclosed are O-protected compounds of the formula (I):wherein B is an optionally protected nucleobase, and R1-R3 are as described herein, a method of preparing such compounds, and a method of preparing oligonucleotides such as RNA starting from such compounds. The O-protected compounds have one or more advantages, for example, the 2'-O-protected compound is stable during the various reaction steps involved in oligonucleotide synthesis; the protecting group can be easily removed after the synthesis of the oligonucleotide, for example, by reaction with tetrabutylammonium fluoride; and/or the O-protected groups do not generate DNA/RNA alkylating side products, which have been reported during removal of 2'-O-(2-cyanoethyl)oxymethyl or 2'-O-[2-(4-tolylsulfonyl)ethoxymethyl groups under similar conditions.