1369385-94-3Relevant articles and documents
Photooxygenations in a bubble column reactor
Yavorskyy, Alexander,Shvydkiv, Oksana,Limburg, Carolin,Nolan, Kieran,Delaure, Yan M. C.,Oelgemoeller, Michael
, p. 888 - 892 (2012)
A novel column reactor was constructed and successfully applied to dye-sensitized photooxygenation reactions in aqueous alcohol solutions. The air flow pattern within the narrow glass column could be controlled via the size of the air inlet capillary. Using a 500 μm capillary, a slug flow pattern was realized which allowed for superior mass transfer and light transparency within a thin solvent layer. These features subsequently gave higher conversion rates and isolated yields.
Efficient photosensitized oxygenations in phase contact enhanced microreactors
Park, Chan Pil,Maurya, Ram Awatar,Lee, Jang Han,Kim, Dong-Pyo
, p. 1941 - 1945 (2011)
A transparent dual-channel microreactor with highly enhanced contact area-to-volume ratio was fabricated for efficient photosensitized oxygenations. The dual-channel microreactor shielded with polyvinylsilazane (PVSZ) consisting of an upper channel for liquid flow and a lower channel for O2 flow, allows sufficient phase contact along the parallel channels through a gas permeable PDMS membrane for maintaining the O2 saturated solution. Under full exposure of reactants to light, the reactions in high concentration are completed in minutes rather than hours that it takes to complete in a batch reactor. Moreover, the scale-up process using the microreactor revealed higher productivity than the batch reactor, which would be valuable for the practical applications in a broad range of gas-liquid chemical reactions.
Synthesis and Photophysical and Photocatalytic Properties of a Highly Fluorinated and Durable Phthalocyanine-Peptide Bioconjugate for Potential Theranostic Applications
Carrión, Erik N.,Santiago, Jenyffer,Sabatino, David,Gorun, Sergiu M.
, p. 7210 - 7216 (2017)
The functionalized, asymmetric fluoro-fluoroalkyl scaffold F48H7COOHPcZn (3) was used to prepare F48H7COOPcZn-6-amino-hexanoate-CTVALPGGYVRVC (5), a Pep42 peptide bioconjugate envisioned for photodynamic therapy, which can specifically target the GRP78 chaperone protein overexpressed and exclusively localized on some cancer cell surfaces. The analogous F48H7COOHPcCu (4) has also been prepared, and its single-crystal X-ray structure was elucidated. Despite reduced steric hindrance relative to the nonfunctionalized, single-site complexes of the F64Pc scaffold, no aggregation was detected in solution via UV-vis spectroscopy, for either 3, 4, or 5, consistent with the lack of π stacking observed for the crystalline 4. The 6-aminohexanoic acid-Pep42 moiety diminishes the fluorescence efficiency of 5, relative to 3, but for singlet oxygen (1O2) generation, photochemical hydroperoxidation of β-(-)-citronellol using 5 and 3 occurs with comparable substrate turnover efficiency, albeit at a slower initial triplet oxygen uptake for 5. The bioconjugate 5 is durable; it does not decompose under 1O2 photoreaction conditions. These results suggest a synthetic coupling pathway for obtaining diverse biotargeting polypeptide-fluorinated phthalocyanine bioconjugates of potential utility as both fluorescence reporters and photocatalysts and highlight the importance of fluorinated scaffolds for generating chemically resilient, catalytic, theranostic materials.
Triple-channel microreactor for biphasic gas-liquid reactions: Photosensitized oxygenations
Maurya, Ram Awatar,Park, Chan Pil,Kim, Dong-Pyo
, p. 1158 - 1163 (2011)
A triple-channel microreactor fabricated by means of a soft-lithography technique was devised for efficient biphasic gas-liquid reactions. The excellent performance of the microreactor was demonstrated by carrying out photosensitized oxygenations of α-terpinene, citronellol, and allyl alcohols.
Chemically robust fluoroalkyl phthalocyanine-oligonucleotide bioconjugates and their GRP78 oncogene photocleavage activity
Patel, Pradeepkumar,Patel, Hemantbhai H.,Borland, Emily,Gorun, Sergiu M.,Sabatino, David
supporting information, p. 6309 - 6311 (2014/06/09)
The first representative of functionalized fluoroalkyl phthalocyanines, F48H7(COOH)PcZn, is reported. The complex generates 1O2 affording long-lasting photooxidation of an external substrate without self-decompo
A versatile synthetic strategy for nanoporous gold-organic hybrid materials for electrochemistry and photocatalysis
Wichmann, Andre,Schnurpfeil, Günter,Backenk?hler, Jana,Kolke, Lena,Azov, Vladimir A.,W?hrle, Dieter,B?umer, Marcus,Wittstock, Arne
, p. 6127 - 6133 (2014/12/10)
Nanoporous gold (npAu) was employed as high surface area substrate for immobilization of redox- and photooxidative-active organic molecules. A two-step synthetic routine is demonstrated as a versatile and robust method for immobilization of various molecu
A versatile synthetic strategy for nanoporous gold-organic hybrid materials for electrochemistry and photocatalysis
Wichmann, Andre,Schnurpfeil, Günter,Backenk?hler, Jana,Kolke, Lena,Azov, Vladimir A.,W?hrle, Dieter,B?umer, Marcus,Wittstock, Arne
, p. 6127 - 6133 (2015/03/30)
Nanoporous gold (npAu) was employed as high surface area substrate for immobilization of redox- and photooxidative-active organic molecules. A two-step synthetic routine is demonstrated as a versatile and robust method for immobilization of various molecu