136944-13-3Relevant academic research and scientific papers
Derivatives of caffeic acid, a natural antioxidant, as the basis for the discovery of novel nonpeptidic neurotrophic agents
Moosavi, Fatemeh,Hosseini, Razieh,Rajaian, Hamid,Silva, Tiago,Magalh?es e Silva, Diogo,Saso, Luciano,Edraki, Najmeh,Miri, Ramin,Borges, Fernanda,Firuzi, Omidreza
, p. 3235 - 3246 (2017)
Neurodegenerative disorders, such as Parkinson's disease and Alzheimer's disease, threaten the lives of millions of people and the number of affected patients is constantly growing with the increase of the aging population. Small molecule neurotrophic age
Optimization of physicochemical properties is a strategy to improve drug-likeness associated with activity: Novel active and selective compounds against Trypanosoma cruzi
Amaral, Maiara,Romanelli, Maiara M.,Tempone, Andre G.,Varela, Marina T.,de Castro Levatti, Erica V.,Fernandes, Jo?o Paulo S.
, (2022/01/31)
Trypanosoma cruzi is the causing agent of Chagas disease, a parasitic infection without efficient treatment for chronic patients. Despite the efforts, no new drugs have been approved for this disease in the last 60 years. Molecular modifications based on
Bio-inspired benzo[k,l]xanthene lignans: Synthesis, DNA-interaction and antiproliferative properties
Spatafora, Carmela,Barresi, Vincenza,Bhusainahalli, Vedamurthy M.,Di Micco, Simone,Musso, Nicolo,Riccio, Raffaele,Bifulco, Giuseppe,Condorelli, Daniele,Tringali, Corrado
, p. 2686 - 2701 (2014/05/06)
In this work twelve benzo[k,l]xanthene lignans were synthesized by biomimetic, Mn-mediated oxidative coupling of caffeic esters and amides. These compounds, bearing different flexible pendants at position C1/C2 of the aromatic core, interact with DNA in a dual mode, as confirmed by DF-STD NMR analysis and molecular docking: the planar core acts as a base pair intercalant, whereas the flexible pendants act as minor groove binders. Their antiproliferative activity was evaluated on a panel of six tumor cell lines: HT-29, Caco-2, HCT-116 (human colon carcinoma), H226, A549 (human lung carcinoma), and SH-SY5Y (human neuroblastoma). All compounds under study, except 29, resulted in activity against one or more cell lines, and the markedly lipophilic esters 13 and 28 showed the highest activity. Compound 13 was more active than the anticancer drug 5-fluorouracil (5-FU) towards HCT-116 (colon, GI50 = 3.16 μM) and H226 (lung, GI50 = 4.33 μM) cell lines. This journal is the Partner Organisations 2014.
Simple amidation of unprotected phenol-containing 2-alkenoic acids
Morais, Goreti Ribeiro,Watanabe, Masataka,Tanaka, Yasuko,Thiemann, Thies
, p. 802 - 807 (2007/10/03)
A series of amides of 2-E-alkenoic acids have been synthesised through the activation of these acids with dicyclohexylcarbodiimide / pentafluorophenol and further reaction with amines under microwave irradiation. In daylight, the E-configured amides under
