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Upstream product

• 948-65-2 2-phenyl-indole 
• 59014-89-0 bis(3-methoxyphenyl)disulfide 
• 1561023-51-5 sodium S-(3-methoxyphenyl) thiosulfate 
• 120-72-9 indole 
• 15570-12-4 3-methoxybenzenethiol 
• 199277-23-1 1-azido-2-(phenylethynyl)benzene 

Relevant academic research and scientific papers

Synthesis of 3-Sulfenylindoles from Indoles and Various Sulfenylation Agents through Aerobic Oxidative C-S Bond Coupling

A novel aerobic catalytic oxidation system for the sulfenylation of indoles with a variety of sulfenylation agents through oxidative C-S bond coupling has been successfully developed. The reactions were performed with potassium iodide as the catalyst, sodium nitrite as the co-catalyst, and molecular oxygen as the terminal oxidant in the presence of acetic acid. Under the optimal reaction conditions, a number of indoles could be sulfenylated with Bunte salts, thiols, or disulfides to generate 3-sulfenylindoles in good yields. This protocol provided an efficient and environmentally benign strategy for the synthesis of 3-sulfenylindoles.

3 - Mercapto of indole compounds synthesized by catalytic oxidation method (by machine translation)

The invention discloses a 3 - mercapto of indole compounds synthesized by catalytic oxidation method, to indole compounds and sulfur on behalf of the sulfate as the substrate of reaction, to potassium iodide and sodium nitrite as catalyst, in order to acetic acid as an auxiliary agent, in order to oxygen as the oxidizing agent, the reaction substrate in the organic solvent, for normal pressure, temperature 50 - 80 °C reaction under the condition of, after the reaction is completed after the separation and processed to obtain the 3 - mercapto-indole compounds. The synthesizing method of the invention, simple and safe operation, in order to clean the oxygen as terminal oxidant, thereby greatly reducing the environmental costs; mild reaction conditions. (by machine translation)

Nitrosonium ion catalysis: aerobic, metal-free cross-dehydrogenative carbon-heteroatom bond formation

Catalytic cross-dehydrogenative coupling of heteroarenes with thiophenols and phenothiazines has been developed under mild and environmentally benign reaction conditions. For the first time, NOx+ was applied for catalytic C-S and C-N bond formation. A comprehensive scope for the C-H/S-H and C-H/N-H cross-dehydrogenative coupling was demonstrated with >60 examples. The sustainable cross-coupling conditions utilize ambient oxygen as the terminal oxidant, while water is the sole by-product.

Visible-Light-Mediated Eosin Y Photoredox-Catalyzed Vicinal Thioamination of Alkynes: Radical Cascade Annulation Strategy for 2-Substituted-3-sulfenylindoles

An organic dye photoredox-catalyzed regiospecific radical cascade annulation strategy of 2-alkynyl-azidoarenes to generate 3-sulfenylindoles via vicinal thioamination of alkynes at room temperature, mediated by visible light, was developed. The method req

Catalytic Synthesis of 3-Thioindoles Using Bunte Salts as Sulfur Sources under Metal-Free Conditions

An efficient catalytic method for the synthesis of 3-thioindoles has been successfully developed, which uses odorless, stable, readily available crystalline Bunte salts as the sulfenylating agents, iodine as nonmetallic catalyst, and DMSO as both the oxid

Preparation method of 3-indole thioether

According to the invention, Bunte salt is employed as a sulfur source to prepare 3-indole thioether. At a certain temperature, elementary iodine or hydroiodic acid and salts thereof is employed as a catalyst, dimethyl sulfoxide is employed as an oxidant,

Venting-while-heating microwave-assisted synthesis of 3-arylthioindoles

We report the first example of venting-while-heating microwave-assisted synthesis of a small library of 3-arylthioindoles. Compounds were prepared in excellent isolated yields (90-98%) within 4 min in a closed vessel by treating indoles with disulfides in the presence of sodium hydride in anhydrous N,N-dimethylformamide. The method was not affected by electron-donating and -withdrawing substituents both on 3-arylthio moiety and at 2- and 5-positions of the indole nucleus.