136967-30-1Relevant academic research and scientific papers
Synthesis of enantiomeric aminophosphonic acids and peptides
Kukhar, Valery,Solodenko, Vladimir,Soloshonok, Vadim,Kasheva, Tamara
, p. 529 - 532 (2007/10/03)
Synthesis of enantiomeric amino phosphonic acids APA is described by using chiral auxiliary reagent or enzymatic resolution of racemic mixtures of APA phenacyl derivatives.Peptides with APA residue were obtained by application of trimethylsilyl derivatives or condensation in the presence of enzyme-papain. - Keywords: aminophosphonic acids, enantiomers, peptides, enzymes
Preparation of N-acylated phosphonopeptides with free phosphonic group
Solodenko,Kasheva,Kukhar
, p. 1631 - 1641 (2007/10/02)
Aminoalkylphosphonic acids on heating with hexamethyldisilazane yield tris(trimethylsilyl) derivatives, which are used as amino components for the synthesis of N-acylated phosphonopeptides with free phosphonic group. These transformations proceed with complete retention of the stereoconfiguration of aminophosphonate moiety.
