1369787-03-0

Basic information

• Product Name: 1-(4-(aminosulfonyl)phenyl)-5-phenyl-1H-tetrazole
• Synonyms: 1-(4-(aminosulfonyl)phenyl)-5-phenyl-1H-tetrazole
• CAS NO: 1369787-03-0
• Molecular Weight: 301.329
• Mol File: 1369787-03-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-(4-(aminosulfonyl)phenyl)-5-phenyl-1H-tetrazole(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-(aminosulfonyl)phenyl)-5-phenyl-1H-tetrazole(1369787-03-0)
• EPA Substance Registry System: 1-(4-(aminosulfonyl)phenyl)-5-phenyl-1H-tetrazole(1369787-03-0)

Safety Data

• Hazardous Substances Data: 1369787-03-0(Hazardous Substances Data)

Upstream product

• 65-85-0 benzoic acid 
• 4389-07-5 N-(4-(aminosulfonyl)phenyl)benzamide 

Relevant articles and documents

Novel 5-substituted 1H-tetrazoles as cyclooxygenase-2 (COX-2) inhibitors

A series of novel 5-substituted 1H-tetrazoles as cyclooxygenase-2 (COX-2) inhibitors was prepared via treatment of various diaryl amides with tetrachlorosilane/sodium azide. All compounds were tested in cyclooxygenase (COX) assays in vitro to determine COX-1 and COX-2 inhibitory potency and selectivity. Tetrazoles contained a methylsulfonyl or sulfonamide group as COX-2 pharmacophore displayed only low inhibitory potency towards COX-2. Most potent compounds showed IC50 values of 6 and 7 μM for COX-2. All compounds showed IC50 values greater 100 μM for COX-1 inhibition.