1369787-86-9Relevant academic research and scientific papers
Synthesis and biological investigation of the β-thiolactone and β-lactam analogs of tetrahydrolipstatin
Aubry, Sylvain,Aubert, Genevieve,Cresteil, Thierry,Crich, David
, p. 2629 - 2632 (2012/04/23)
The synthesis of β-thiolactone and β-lactam analogs of tetrahydrolipstatin is described from a common late-stage β-lactone derivative. These analogs, and a cis-disubstituted β-lactone analog of tetrahydrolipstatin, were screened for activity against porcine pancreatic lipase and for inhibition of cell growth of a panel of four human cancer lines. The Royal Society of Chemistry 2012.
