136982-89-3

Usage

Explanation

The molecular formula represents the number of atoms of each element present in a molecule of the compound.

Explanation

Pyrimidine is a heterocyclic aromatic organic compound with the formula C4H4N2. 1-[(2R,4R)-2-(hydroxymethyl)-1,3-dioxolan-4-yl]-5-methylpyrimidine-2,4(1H,3H)-dione is derived from the pyrimidine ring, indicating its structure and potential chemical properties.

Explanation

The hydroxymethyl group is attached to the dioxolane ring, providing additional functional groups and potential reactivity.

Explanation

The methyl group is attached to the pyrimidine ring, further modifying the compound's structure and properties.

Explanation

Chirality refers to the presence of a chiral center, which is an atom bonded to four different groups. In this case, the compound has two chiral centers, which can lead to different stereoisomers.

Explanation

The compound's structure and functional groups suggest that it could have potential uses in drug development or other biological applications, but further research is needed to confirm these possibilities.

Explanation

While the compound's structure and functional groups provide some insight into its potential properties and applications, more research is required to fully understand its characteristics and potential uses.

Pyrimidine derivative

A compound derived from the pyrimidine ring structure.

Dioxolane group

A five-membered ring containing two oxygen atoms.

Hydroxymethyl group

A functional group with the formula -CH2OH.

Methyl group

A functional group with the formula -CH3.

Chirality

The compound has two chiral centers at the 2R and 4R positions.

Potential pharmaceutical or biological applications

The compound's unique structure and functional groups may have applications in the pharmaceutical or biological fields.

Further research needed

The specific properties and potential uses of the compound are not yet fully understood.

Upstream product

• 127658-05-3 1-((2S,4S)-2-Benzyloxymethyl-[1,3]dioxolan-4-yl)-5-methyl-1H-pyrimidine-2,4-dione 
• 136884-16-7 1-[(2R,4R)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-[1,3]dioxolan-4-yl]-5-methyl-1H-pyrimidine-2,4-dione 
• 136884-16-7 (-)-(2R,4R)-1-<2-<<(tert-butyldiphenylsilyl)oxy>methyl>-1,3-dioxolan-4-yl>thymine 
• 229635-18-1 (2R)-4-acetoxy-2-<<(tert-butyldiphenylsilyl)oxy>methyl>dioxolane 
• 7288-28-0 2,4-bis(trimethylsiloxy)-5-methylpyrimidine 
• 65-71-4 thymin 

Downstream Products

• 1138242-30-4 dioxolane-thymine 5'-O-cyclohexanecarboxylic ester 
• 1138242-37-1 dioxolane-thymine 5'-O-D-phenylalanyl ester hydrochloride 
• 1138242-36-0 dioxolane-thymine 5'-O-L-phenylalanyl ester hydrochloride 
• 1142817-42-2 C₂₁H₂₆N₃O₉P 
• 1142817-38-6 C₁₉H₂₂Cl₂N₃O₉P 
• 1142817-32-0 C₂₂H₃₀N₃O₉P 
• 1142817-30-8 C₂₁H₂₇BrN₃O₉P 
• 1142817-39-7 C₁₉H₂₄N₃O₉P 
• 1142817-41-1 C₂₄H₂₆N₃O₉P 
• 1142817-33-1 C₂₂H₃₀N₃O₉P 
• 1142817-35-3 C₂₆H₃₀N₃O₉P 
• 1142817-34-2 C₂₁H₂₈N₃O₉P 
• 1142817-36-4 C₂₆H₃₀N₃O₁₀P 
• 1142819-31-5 C₂₀H₂₆N₃O₉P 

Relevant academic research and scientific papers

2-Substituted-4-substituted-1,3-dioxolanes and use thereof

Nucleoside analogues containing a 1,3-dioxolane structure are suitable antiviral agents, particulary for the treatment of the HIV infections in mammals, especially humans. Examples of the nucleoside analogues include: cis-2-acetoxymethyl-4-(thymin-1′-yl)-1,3,-dioxolane, cis-2-hydroxymethyl-4-(thymin-1′-yl)-1,3-dioxolane, cis-2-benzoyloxymethyl-4-(cytosin-1′-yl)-1,3-dioxolane, and cis-2-hydroxymethyl-4-(cytosin-1′-yl)-1,3-dioxolane. These compounds can be in the form of their racemates or their separate enantiomers.

Enantiomerically pure β-D-dioxolane-nucleosides

A method and composition for the treatment of humans infected with HIV that includes the administration of an HIV treatment amount of an enantiomerically pure β-D-dioxolanyl purine nucleoside of the formula: STR1 wherein R is OH, Cl, NH2, or H,

Process for the preparation of enantiomerically pure β-D-(-)-dioxolane-nucleosides

An asymmetric process for the preparation of enantiomerically pure β-D-(-)-dioxolane-nucleosides. The enantiomerically pure dioxolane nucleosides are active HIV agents, that are significantly more effective than the prior prepared racemic mixtures of the

Divergent Asymmetric Syntheses of Dioxolane Nucleoside Analogues

Oxidative degradation of benzyloxymethylacetals derived from D-mannitol or L-ascorbic acid provides dioxolane intermediate 6 and 7 useful in the synthesis of all the stereoisomers of dioxolane nucleoside analogues.

Asymmetric Synthesis of 1,3-Dioxolane-Pyrimidine Nucleosides and Their Anti-HIV Activity

In order to study the structure-activity relationships of dioxolane nucleosides as potential anti-HIV agents, various enantiomerically pure dioxolane-pyrimidine nucleosides have been synthesized and evaluated against HIV-1 in human peripheral blood mononuclear cells.The enantiomerically pure key intermediate 8 has been synthesized in nine steps from 1,6-anhydro-D-mannose (1), which was condensed with 5-substituted pyrimidines to obtain various dioxolane-pyrimidine nucleosides.Upon evaluation of these compounds, cytosine derivative 19 was found to exhibit the most potent anti-HIV agent although it is the most toxic.The order of anti-HIV potency was as follows: cytosine (β-isomer) > thymine > cytosine (α-isomer) > 5-chlorouracil > 5-bromouracil > 5-fluorouracil derivatives.Uracil, 5-methylcytosine, and 5-iodouracil derivatives were found to be inactive.Interestingly, α-isomer 20 showed good anti-HIV activity without cytotoxicity.As expected, other α-isomers did not exhibit any significant antiviral activity. (-)-Dioxolane-T was 5-fold less effective against AZT-resistant virus than AZT-sensitive virus.

Asymmetric synthesis of enantiomerically pure (-)-(1'R,4'R)-dioxolane-thymine and its anti-HIV activity

An asymmetric synthesis leading to the enantiomerically pure dioxolane-T has been achieved and its crystal structure has been determined and compared to the previously reported racemate. (-)-(1'R,4'R)-dioxolane-T was found to have potent and selective ant

(±)-Dioxolane-T ((±)-1-[(2β,4β)-2-(hydroxymethyl)-4-dioxolanyl]thymine). A new 2',3'-dideoxynucleoside prototype with in vitro activity against HIV

A novel analogue of 3'-deoxythymidine, in which the 3'-carbon is replaced by oxygen, was synthesized in 5 steps from benzyloxyacetaldehyde dimethyl acetal and (±)-methyl glycerate. In ATH8 cells, this analogue showed significant inhibition of the infectiv